REVIEW article
Front. Med.
Sec. Gastroenterology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1620079
Probiotics in inflammatory bowel diseases：Emphasis on Mechanisms and Clinical Application
Provisionally accepted
- 1Department of Urology, the First Affiliated Hospital of Dalian Medical University, Dalian, China
- 2College of Basic Medical Sciences, Dalian Medical University, Dalian, China
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Inflammatory bowel disease (IBD) is a group of diseases characterized by chronic intestinal inflammation including Crohn's disease (CD) and ulcerative colitis (UC). In recent years, probiotics have attracted more and more attention as a potential adjuvant therapy. Probiotics can improve the symptoms and quality of life of IBD patients mainly by regulating intestinal microflora, regulating immune response, enhancing intestinal barrier function and exerting anti-inflammatory effect. However, although a large number of studies have explored the role of probiotics, there are still individual differences and uncertainties in clinical application. This paper reviews the mechanism, clinical effect and future prospect of probiotics in the treatment of IBD, and analyzes the existing clinical research and experimental data to provide reference for further research. Finally, this paper looks forward to the research direction of probiotics in the treatment of IBD, aiming at providing evidence for clinical practice.
Keywords: Probiotics, inflammatory bowel disease, Crohn's disease, ulcerative colitis, Gut Microbiota
Received: 29 Apr 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 Zhang, Zhang, Cheng, Wang, Lv, Zheng and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xu Zheng, College of Basic Medical Sciences, Dalian Medical University, Dalian, China
Guangzhen Wu, Department of Urology, the First Affiliated Hospital of Dalian Medical University, Dalian, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.