ORIGINAL RESEARCH article
Front. Med.
Sec. Ophthalmology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1620673
This article is part of the Research TopicNew Concepts, Advances, and Future Trends in Clinical Research on Eye DiseasesView all 53 articles
Macular Vascular Density Changes in Different Stages of Chronic Primary Angle-Closure Glaucoma
Provisionally accepted
- 1Shanghai Tenth People's Hospital, Tongji University, Shanghai, China
- 2The Affiliated People’s Hospital of Ningbo University, Ningbo, China
- 3Ningbo Key Laboratory of Medical Research on Blinding Eye Diseases, Ningbo Eye Institute, Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, China
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Objective: This study aims to investigate differences in macular vascular density (MVD) between individuals with chronic primary angle-closure glaucoma (CPACG) and healthy controls, as well as to evaluate cross-sectional changes in MVD at various stages of CPACG. Method: This is a retrospective study based on the epidemiological survey of eye diseases in the local community, including 47 eyes of CPACG subjects (20 eyes at early stage and 27 eyes at the middle-to-severe stages). All subjects underwent optical coherence tomography angiography (OCTA) imaging to detect MVD, as well as macular retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness. Linear regression analysis was performed to evaluate other ophthalmic indicators related to vascular density loss. Result: Compared with the control group, the MVD in CPACG eyes was significantly declined by 11.5% in superficial capillary plexus (P=0.012), and 6.8% in deep capillary plexus.Single correlation analysis showed that MVD in CPACG eyes was significantly correlated with axial length (r=0.493, P=0.036), RNFL thickness (r=0.488, P=0.047), and mean deviation of visual field (r=-0.546, P=0.010). In addition, multiple regression analysis also suggested that MVD was positively correlated with GCL/RNFL thickness and negatively correlated with mean deviation of visual field (P=0.004). Conclusion: Our study demonstrated that OCTA was a valuable tool for detecting vascular deterioration in CPACG eyes, with a stronger association between MVD and visual field damage. Further research is warranted to explore the potential of MVD as a biomarker for glaucoma progression.
Keywords: Primary angle closure glaucoma, Macular vascular density, visual field defects, macular retinal nerve fiber layer, Ganglion cell layer, optical coherence tomography angiography
Received: 30 Apr 2025; Accepted: 07 Jul 2025.
Copyright: © 2025 Zhang, Lu, Yu, Liu, Yang, Wang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Fang Wang, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China
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