ORIGINAL RESEARCH article
Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1620973
The Role of Xuanfei Zhisou Mixture Plus Fluticasone Propionate Suspension in the Treatment of Variant Cough in Children and Its Effect on Serum Amyloid A and C-reactive Protein
Provisionally accepted
- Shijiazhuang Maternal and Child Health Hospital, Shijiazhuang, China
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Background: Albeit fluticasone propionate suspension is effective in treating variant cough in children, there is limited research on the use of Xuanfei Zhisou mixture, and even fewer studies on its combination application. This study aimed to estimate the role of Xuanfei Zhisou mixture (XZM) plus fluticasone propionate suspension (FPS) in the treatment of cough variant in children. Methods: 122 children with variant cough from March 2020 to May 2023 were classified into observation therapy (XZM + FPS, n = 60) and control therapy (FPS, n = 60) using block randomization. The clinical effect, inflammatory factor, pulmonary function, peripheral eosinophil count, daytime and nighttime cough scores, immune function and untoward reactions were contrasted in two groups. Results: The clinical effect, Forced Vital Capacity (FVC), FEV1 (Forced Expiratory Volume)/FVC, CD3+, CD4+ as well as CD4+/CD8+ of the observation therapy were higher than control therapy. After treatment, interleukin-4 (IL-4), tumor necrosis factor-α (TNF-α), serum amyloid A (SAA), c-reactive protein (CRP), eosinophil count as well as daytime and nighttime cough scores in observation therapy were lower than control therapy. Howbeit, there was no diversity in untoward reactions between the two groups. Conclusion: XZM plus FPS had conspicuous role in children with variant cough, which assisted in diminishing cough symptoms, raising pulmonary function, reduce inflammatory factor level and upgrading immune function of children.
Keywords: inflammatory factor level, Immune function, fluticasone propionate suspension, Xuanfei Zhisou mixture, Pulmonary Function, variant cough in children
Received: 30 Apr 2025; Accepted: 25 Sep 2025.
Copyright: © 2025 Zhang, Song, Xue and Xue. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ning-Ning Xue, xueningning1@outlook.com
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