ORIGINAL RESEARCH article
Front. Med.
Sec. Hematology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1621569
This article is part of the Research TopicInnovative Modeling and Simulation in Thrombosis and Hemostasis: Enhancing Diagnosis and TreatmentView all 3 articles
Combined Role of Thromboelastography and Coagulation Indicators in Predicting Thromboembolism Risk in Cancer Patients
Provisionally accepted
- 1Tangshan Central Hospital, Tangshan, China
- 2Tangshan Fengnan district Hospital, Tangshan, China
- 3Affiliated Hospital of North China University of Science and Technology, Tangshan, China
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Objective: Exploring the application value of thromboelastography (TEG) and four coagulation indicators in the risk assessment of thromboembolism (TE) in cancer patients. Methods: Retrospectively analyzed the clinical data of 160 cancer patients. Among them, 45 patients experienced thromboembolism (TE group) and 115 patients did not experience thromboembolism (Non-TE group). We analyzed the levels of TEG and coagulation indicators in the two groups of patients and the risk factors for TE in cancer patients. Results: The Angle and MA of the thromboembolic group were significantly higher than those of the Non-TE group, whereas K and R were significantly lower than those of the Non-TE group (P<0.05). D-dimer (D-D) and fibrinogen (FIB) levels in the thromboembolic group were significantly higher than those in the Non-TE group, while activated partial thromboplastin time (APTT), prothrombin time (PT), and platelet count (PLT) were significantly lower than those in the Non-TE group (P<0.05). Binary logistic regression analysis confirmed that angle, maximum amplitude (MA), K, R, D-D, APTT, PT, and PLT were all important influencing factors for the occurrence of TE in cancer patients (P<0.05). Conclusions: TEG and coagulation index level detection have high application values in the risk assessment of TE in cancer patients.Core Tips: 1. TEG can measure the stability, strength, and formation rate of blood clots; To comprehensively evaluate the functions of fibrinolytic substances, platelets, and coagulation factors.2. TEG and coagulation index level detection have high application values in the risk assessment of TE in cancer patients.
Keywords: Thromboelastography, Coagulation indicators, Thromboembolism, cancer patients, risk
Received: 01 May 2025; Accepted: 04 Aug 2025.
Copyright: © 2025 Huang, Dong, Hu, Wang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Liqiu Huang, Tangshan Central Hospital, Tangshan, China
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