CASE REPORT article
Front. Med.
Sec. Nephrology
This article is part of the Research TopicManagement of Patients with Dialysis Dependent Chronic Kidney Disease (DD-CKD)View all 9 articles
Paradoxical Effects of Parathyroidectomy and Sodium Thiosulfate in a Hemodialysis Patient with Calciphylaxis: A Case Report of Persistent Metastatic Calcification
Provisionally accepted
- Affiliated Hospital of Weifang Medical University, Weifang, China
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Calcific uraemic arteriolopathy (CUA) is a rare and life-threatening condition characterized by vascular calcification, commonly observed in patients with end-stage kidney disease (ESKD). CUA is associated with a high 1-year mortality rate, ranging from 45% to 80%. Despite existing therapeutic options, managing CUA remains challenging with limited outcomes. This case report discusses a patient with ESKD undergoing long-term hemodialysis, who developed progressive CUA despite undergoing parathyroidectomy (PTX). Although sodium thiosulfate (STS) treatment promoted significant healing of skin ulcers, it had limited effects on tumoral calcinosis. This paradoxical clinical outcome highlights the complexity of managing CUA and underscores the need for a multimodal intervention strategy.
Keywords: end-stage kidney disease, Sodium thiosulfate, Calcific UremicArteriolopathy, Tumoral calcinosis, multimodal therapy
Received: 04 May 2025; Accepted: 03 Nov 2025.
Copyright: © 2025 罗, Xu, Li, zhu, sun, wang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
jinling wang, wfwjl001@126.com
xuexun Chen, fyxuexun_chen@sdsmu.edu.cn
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