ORIGINAL RESEARCH article
Front. Med.
Sec. Rheumatology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1623557
Ser um Ur ic Acid Pr edictive Value and Pr ognostic Impact in Rheumatoid Ar thr itis-Associated Inter stitial Lung Disease
Provisionally accepted
- 1Chongqing Medical University, Chongqing, China
- 2the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
- 3Affiliated Hospital of Chengdu University, Chengdu, China
- 4Chongqing General Hospital, Chongqing, China
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It is critical to identify novel biomarkers for the predictive and prognostic of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Objective: To investigate the predictive and prognostic significance of serum uric acid (UA) in RA-ILD. Design, setting, and par ticipants: In this multicenter retrospective cohort study, demographic data, medical history and laboratory results of 829 RA patients were extracted from the electronic medical records between December 2018 and January 2024. The cohort was divided into RA-ILD group (n=351) and RA-no-ILD group (n=478).Main outcomes and measur es: The primary endpoint was predictive capacity of baseline UA levels for incident ILD in RA patients. The secondary endpoint was the all-cause mortality and rehospitalization rate in RA-ILD patients.Results Univariate analysis identified elevated UA as a significant risk factor for ILD development in RA patients (OR [95% CI]: 1.68 [1.23-2.28], p=0.001). Multivariate analysis confirmed that elevated UA remained an independent risk factor. Subgroup analysis demonstrated stronger predictive utility of elevated UA in younger RA patients (age < 65) with shorter disease duration and absence of comorbidities (OR [95% CI]: 3.66 [1.66-8.05], p=0.001; AUCROC=0.718). During follow-up, RA-ILD patients with elevated UA exhibited significantly higher all-cause mortality (22.1% vs. 13.1%; HR [95% CI]: 1.80 [1.03-3.17], p=0.040) and rehospitalization rates (51.9% vs. 44.4%; HR [95%
Keywords: Rheumatoid arthritis, Interstitial Lung Disease, Uric Acid, Predictive Value, prognostic impact
Received: 06 May 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 Hu, Cheng, Lan, Lei, Niu and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Changchun Niu, Chongqing Medical University, Chongqing, China
Yang Luo, Chongqing Medical University, Chongqing, China
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