SYSTEMATIC REVIEW article
Front. Med.
Sec. Precision Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1623940
Bibliometric analysis of Biologic Treatments for Chronic Rhinosinusitis (CRS)
Provisionally accepted
- Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China
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Chronic rhinosinusitis (CRS) significantly impacts patients' quality of life. The use of biologic therapies in CRS management has gained traction in clinical practice.However, no bibliometric analysis has been conducted in this area thus far. This study aims to provide a comprehensive overview of the knowledge framework and research trends regarding biologic treatments for CRS.A bibliometric analysis was performed on 888 publications related to biologic treatments for CRS, published between 2011 and 2024. Literature was retrieved from the Web of Science (WoS), and data visualization and trend analysis were conducted using VOSviewer, CiteSpace, and Bibliometrix software tools.on biologic therapies for CRS peaked in the past six years. Key contributors include Claus Bachert, the USA, and the University of Ghent. The most cited article is "Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicenter, randomized, double-blind, placebo-controlled, parallel-group phase 3 trials." The five most explosive keywords are: expression (5.03), placebo-controlled trial (3.68), anti-IgE (3.35), anti-IgE antibody (3.22), and phenotypes (4.55). Current research on biologic treatments for CRS predominantly focuses on clinical applications.This study offers a bibliometric visualization of the literature on biologic treatments for CRS, highlighting key developments and emerging research trends in the field. It provides valuable references for scholars and outlines future research directions to further advance the field.
Keywords: Chronic rhinosinusitis, Biologic treatments, Bibliometric, Visualized analysis, Emerging trends
Received: 06 May 2025; Accepted: 29 Jul 2025.
Copyright: © 2025 Huang, Chen, LI, Sui, Pan, Yang, Lv, Chen, Yin, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xinrong Li, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China
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