ORIGINAL RESEARCH article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1624554
This article is part of the Research Topic25 Years of 21st Century MedicineView all 8 articles
Clinical Features and Laboratory Indicators of Dengue Infection in China: A Retrospective Study of Adult Patients in a Hospital of Traditional Chinese Medicine
Provisionally accepted
Qilong Nie
Mingyang LiQiuyan LiangJian RenTong LiWenya PengCuifen LuoXiaoai MoXiaojun Ma
Jianhong Li*
Kaiping Jiang*- Guangzhou University of Chinese Medicine, Guangzhou, China
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Background: Dengue is an arboviral disease caused by the dengue virus, primarily transmitted by mosquitoes in tropical and subtropical regions. Despite preventive measures, the incidence and mortality of dengue remain significant. While the acute phase of infection often presents with mild, self-limiting symptoms and may mimic other undifferentiated febrile illnesses, the risk of mortality is particularly high during the acute phase of secondary infections, which are associated with more severe clinical manifestations. Liver dysfunction has been strongly linked to the severity of the disease, and it plays a critical role in determining patient outcomes. Methods: This retrospective observational study was conducted at Foshan Hospital of Traditional Chinese Medicine, including 533 hospitalized dengue patients diagnosed between June and December 2024. Clinical symptoms (e.g., fatigue, headache, muscle pain, dry mouth, rash, nausea) and laboratory parameters (e.g., complete blood count, liver function tests, lactate dehydrogenase, C-reactive protein, procalcitonin) were collected. Patients were categorized into three groups based on liver function test results: non-liver injury (ALT ≤
Keywords: Dengue infection, liver enzymes, Inflammatory markers, Tissue damage, Retrospective observational study
Received: 07 May 2025; Accepted: 26 Jun 2025.
Copyright: © 2025 Nie, Li, Liang, Ren, Li, Peng, Luo, Mo, Ma, Li and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jianhong Li, Guangzhou University of Chinese Medicine, Guangzhou, China
Kaiping Jiang, Guangzhou University of Chinese Medicine, Guangzhou, China
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