CASE REPORT article
Front. Med.
Sec. Dermatology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1626685
Article type: Case report
Provisionally accepted
- Shandong Provincial Hospital, Jinan, China
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Nocardia genus is an aerobic, gram-positive, and opportunistic pathogen, which mainly affects cell-mediated immunosuppressed patients. Clinical manifestation of nocardiosis is a variable spectrum which makes nocardiosis difficult to diagnose. We report a 48-year-old female with muscular abscess induced by Nocardia asteroides. Venous blood, skin biopsy specimen, muscle tissue, and inguinal lymph node puncture tissue culture reported negative results. With the assistant of metagenomic next-generation sequencing (mNGS) , the pathogen was identified as Nocardia asteroides. Whole-exome sequencing of peripheral blood showed that the patient had a monoallelic mutation in the lipopolysaccharide-responsive beige-like anchor protein (LRBA) gene. mNGS identified Nocardia asteroides of the patient and the appliance of accurate treatment made her complete recovery.
Keywords: Nocardia asteroides, Nocardiosis, Muscle abscess, metagenomic next-generation sequencing, LRBA gene mutation
Received: 11 May 2025; Accepted: 18 Aug 2025.
Copyright: © 2025 Yang, Jing and Dang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yamin Yang, Shandong Provincial Hospital, Jinan, China
Ningning Dang, Shandong Provincial Hospital, Jinan, China
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