ORIGINAL RESEARCH article
Front. Med.
Sec. Obstetrics and Gynecology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1626735
Laparoscopic Lateral Suspension combined with Uterosacral Ligament Folding and Shortening versus Laparoscopic Sacrocolpopexy for the Treatment of Pelvic Organ Prolapse: A Retrospective Cohort Study
Provisionally accepted
Xiangpeng Xiong
Leizhen XiaTong MeiJialv Huang
Ting WangYun ZhangShuang WangYe LuoHaiping Liu
Xiaoyan Ai*Liqun Wang*- Jiangxi Maternal and Child Health Hospital, Nanchang, China
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ABSTRACTStudy Objective: This study aimed to compare the efficacy of Laparoscopic Lateral Suspension (LLS) combined with uterosacral ligament folding and shortening versus Laparoscopic Sacrocolpopexy (LSC) for treating pelvic organ prolapse (POP). Design: A Retrospective Cohort Study.Setting: Department of Gynecology, Jiangxi Maternal and Child Health HospitalPatients: A total of 445 women with POP-Q stage ≥ II, were included into two groups: 232 in the LSC group and 213 in the LLS combined with uterosacral ligament folding and shortening (LLS-ULFS) group. Interventions: None.Measurements and Main results: During the 2-year follow-up, the anatomic success rates for the apical, anterior and posterior compartments were 96.98%, 94.40%, and 96.12% in the LSC group, respectively, and 94.84%, 96.24% and 94.37% in the LLS-ULFS group. The LLS-ULFS group had significantly lower median operation duration (85 vs. 105 min, P < 0.001), blood loss (40 vs. 50 ml, P < 0.001), and VAS scores (4 vs. 4, P < 0.001) compared to the LSC group. There was no significant difference in length of stay or complications between the two groups (P > 0.05). During the 2-year follow-up, the PFDI-20 (B: 0.15, 95%CI: 0.07~0.23, P=0.001), POPDI-6 (B: 0.17, 95%CI: 0.03~0.30, P=0.014), CRADI-8 (B: 0.92, 95%CI: 0.60~1.25, P<0.001), and PISQ-12 (B: -2.07, 95%CI: -2.54~-1.60, P<0.001) scores were significantly better in the LLS-ULFS group.Conclusion: LLS combined with uterosacral ligament folding and shortening has demonstrated comparable anatomical success and improved quality of life outcomes, making it a viable alternative to LSC for treating POP.
Keywords: uterosacral ligament folding and shortening, Laparoscopic sacrocolpopexy, Pelvic Organ Prolapse, patient-reported outcomes, Laparoscopic lateral suspension
Received: 11 May 2025; Accepted: 22 Jul 2025.
Copyright: © 2025 Xiong, Xia, Mei, Huang, Wang, Zhang, Wang, Luo, Liu, Ai and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaoyan Ai, Jiangxi Maternal and Child Health Hospital, Nanchang, China
Liqun Wang, Jiangxi Maternal and Child Health Hospital, Nanchang, China
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