REVIEW article
Front. Med.
Sec. Ophthalmology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1628325
This article is part of the Research TopicProgress and Perspectives in Surgical Management of GlaucomaView all articles
From Tumor Microenvironment to Ocular Hypertension: Unraveling the Pathogenesis and Therapeutic Strategies of Cancer-Related Glaucoma
Provisionally accepted
- Eye Center, Xiamen University, Xiamen, China
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Cancer is a global health threat, and its incidence and mortality are increasing annually. Cancer-related glaucoma, a severe complication caused by primary or metastatic tumors and their treatments, has complex pathogenic mechanisms. This review aims to clarify the risk factors, classification, diagnosis, and treatment progress of this glaucoma type. Mechanisms include mechanical obstruction, secondary angle closure, neovascularization, inflammation and cytokine release, alterations in aqueous humor dynamics, and secondary hemosiderosis. Clinical manifestations are diverse, such as rapid intraocular pressure increase, neovascular changes, and tumor-related characteristic signs. Treatment requires multidisciplinary cooperation, with primary tumor control as the core, combined with drugs like anti-VEGF agents and targeted therapies, and modified surgeries. Future research should focus on personalized therapeutic strategies, gene therapy applications, integration of multimodal imaging, and optimization of AI models to optimize early intervention and reduce the risk of irreversible optic nerve damage.
Keywords: Cancer-related glaucoma, Pathogenesis, Clinical manifestation, treatment strategies, Multidisciplinary collaboration
Received: 30 May 2025; Accepted: 04 Aug 2025.
Copyright: © 2025 Lin and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bin Lin, Eye Center, Xiamen University, Xiamen, China
Dongkan Li, Eye Center, Xiamen University, Xiamen, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.