ORIGINAL RESEARCH article
Front. Med.
Sec. Translational Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1628781
This article is part of the Research TopicAdvancements in Translational Models: Bridging Basic Infection Research and Clinical ApplicationsView all 6 articles
Effect of remote ischemic postconditioning on hepatic ischemia‒reperfusion injury in patients undergoing laparoscopic hepatectomy: A randomized double-blinded controlled trial
Provisionally accepted
Chao Yang1
Lijun Yang2Mingwang Zeng3Yunyan Zhu1
Chuanwu Zhang1Jing Chen3Yi Wang4Jinji Peng4
Li-feng Wang3Maolin Zhong3Haiyu Xie3
Weidong Liang3*- 1First Clinical Medical College of Gannan Medical University, Ganzhou, China
- 2Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China
- 3Department of Anesthesia Surgery Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- 4Gannan Medical University, Ganzhou, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background Hepatic ischemia‒reperfusion injury (HIRI) remains a major determinant of outcomes after hepatectomy with hepatic portal occlusion. Animal studies suggest that remote ischemic postconditioning (RIPostC) could alleviate HIRI ,but its clinical value is unclear. This trial aimed to evaluate the efficacy of RIPostC in patients undergoing laparoscopic hepatectomy. Methods: In this randomized controlled trial, 83 patients were assigned to receive either RIPostC(4 cycles of 5 min ischemia / 5 min reperfusion) or no intervention. The primary endpoints were postoperative liver function biochemical markers in the serum(alanine aminotransferase [ALT], aspartate aminotransferase [AST], and total bilirubin [TBIL] levels) on postoperative days 1 and 2. The secondary outcomes included intraoperative variables and hospital stay. Results: Data from a total of 72 patients (36 per group) were analyzed. RIPostC did not significantly reduce ALT, AST or TBIL compared with control group(all P>0.05). No differences were observed in Pringle time, operation time or length of postoperative hospital stay (P >0.05). Conclusion: This study represents one of the first randomized controlled clinical evaluations of RIPostC during laparoscopic hepatectomy. Contrary to experimental findings, a single RIPostC protocol did not improve early postoperative liver function.
Keywords: remote ischemic postconditioning, Hepatectomy, ischemia-reperfusion injury, Liver function, laparoscopic surgery
Received: 14 May 2025; Accepted: 15 Sep 2025.
Copyright: © 2025 Yang, Yang, Zeng, Zhu, Zhang, Chen, Wang, Peng, Wang, Zhong, Xie and Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Weidong Liang, lwd0929@gmu.edu.cn
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.