REVIEW article
Front. Med.
Sec. Geriatric Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1630824
This article is part of the Research TopicBone Aging and Osteoporosis: Recent Evidence Focusing on Plant-Based Natural Products - Volume IIView all 4 articles
Application of artificial intelligence-assisted Traditional Chinese medicine formula granules in bone and joint degenerative diseases in the field of holistic health
Provisionally accepted
- 1Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China
- 2The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
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As global aging intensifies, the incidence of degenerative bone and joint diseases such as osteoarthritis bone aging and osteoporosis continues to rise. Traditional treatment methods face bottlenecks in long-term management, including drug side effects and low patient compliance. Traditional Chinese medicine (TCM) formula granules, which utilize plant-based natural products, show excellent clinical efficacy in managing these conditions. With the development of technology, artificial intelligence (AI) technology has enhanced the clinical efficacy of traditional Chinese medicine formula granules through multiple approaches such as intelligent syndrome differentiation and formula optimization, drug efficacy prediction and mechanism analysis, as well as patient management and therapeutic effect monitoring, providing a new approach for the prevention and treatment of complex degenerative diseases. This paper systematically reviews the core advantages of TCM formula granules and their suitability for orthopedic diseases such as bone aging and osteoporosis. It analyzes the application models of AI technology in optimizing TCM formula granules, predicting drug efficacy, and personalized treatment. The main research results show that the artificial intelligence-driven traditional Chinese medicine formula granule system is beneficial for promoting the full-cycle integration of "prevention - treatment - rehabilitation" in the chronic disease management of bone and joint degenerative diseases. However, challenges persist in clinical evidence standardization, algorithm interpretability, and ethical frameworks. Future directions require interdisciplinary technological innovation, policy-industrial synergy, and global collaboration to advance intelligent TCM transformation for degenerative disease management.
Keywords: artificial intelligence, AI assisted, TCM formula granules, plant-based natural products, Bone and joint degenerative diseases, Bone aging and osteoporosis
Received: 18 May 2025; Accepted: 11 Jun 2025.
Copyright: © 2025 Zhang, ZHUOXU, Zhou, Huang, Luo, Zeng and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ling-Feng Zeng, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Wei-Yi Yang, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
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