CASE REPORT article
Front. Med.
Sec. Precision Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1631714
Primary thyroid squamous cell carcinoma with severe respiratory stenosis and endotracheal invasion: a case report with literature review
Provisionally accepted
- Cangzhou People's Hospital, Cangzhou, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Introduction: Primary squamous cell carcinoma of the thyroid (PSCCT) is a rare and highly aggressive malignant tumor with a poor prognosis. Although surgery, chemotherapy and other treatment methods have been reported, the current treatment modality has not reached a consensus. This study discusses the diagnosis and treatment of a case of PSCCT with severe respiratory stenosis and endotracheal invasion and reviews the relevant literature. We report the disease of rapidly enlarging mass leading to asphyxiation to raise clinicians' awareness of this condition.We report a 76-year-old woman presenting with an enlarging right thyroid mass accompanied by severe dyspnea and hoarseness. Computed tomography (CT) scan disclosed a large solid heterogenous nodule with calcification in the right thyroid lobe and prominent adjacent lymph nodes. PSCCT was confirmed by postoperative histopathology and immunohistochemistry. Thyroidectomy with partial tracheectomy and tracheostomy was performed to relieve the patient's dyspnea.The patient has been discharged after receiving post-operative supportive care.Clinicians should pay attention to the rapidly enlarging neck mass as it may cause asphyxiation and avoid the loss of treatment opportunities.
Keywords: thyroid cancer, Primary squamous cell carcinoma, Thryroid, case report, respiratory stenosis
Received: 20 May 2025; Accepted: 11 Jul 2025.
Copyright: © 2025 Liu, Ma, Zheng, Xu, Hao, Ma and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xueliang Liu, Cangzhou People's Hospital, Cangzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.