ORIGINAL RESEARCH article
Front. Med.
Sec. Ophthalmology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1633155
This article is part of the Research TopicNew Concepts, Advances, and Future Trends in Clinical Research on Eye DiseasesView all 56 articles
Study on the Relationship between Lid-parallel Conjunctival Folds and Symptoms and Signs of Dry Eyes Disease
Provisionally accepted
XiangTian Meng
Hongyan Zhou*- China-Japan Union Hospital, Jilin University, Changchun, China
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Exploring the correlation between grade and total number of nasal and temporal side LIPCOFs for signs and dry eye severity grading of different types of dry eye disease.The data of 76 eyes of 38 patients with dry eye disease were selected. Fluorescein Breakup Time(FBUT), tear secretion function, corneal staining test and slit lamp examination were performed. The above results and the grade and total number of nasal and temporal side LIPCOFs were recorded. The causal relationship between parametric variables was analysed by Pearson's correlation, and the causal relationship between non-parametric variables was analysed by Spearman's correlation. Paired t-test was used to analyse statistical differences between different groups. BH-FDR correction is used to reduce the risk of type I error rate inflation when there is a correlation between multiple indicators. Results A significant negative correlation was found between the grade of temporal side LIPCOF and the FBUT in all 76 eyes, aqueous deficiency group and non-aqueous deficiency group.Similarly, temporal side LIPCOF showed a reliable positive correlation with dry eye disease severity grading in the non-aqueous deficiency group, but this correlation was not statistically significant in the aqueous deficiency group. For the grade of nasal side LIPCOF, there was no statistical correlation between the conjunctival fold grade and the FBUT in all 76 eyes, but there was a significant positive correlation between the conjunctival fold grade and the FBUT in the aqueous deficiency group. In the non-aqueous deficiency group, there was a significant negative correlation between the conjunctival fold grade and FBUT. For the total number of LIPCOFs, there was no statistical correlation between the total number of LIPCOFs and FBUT in all 76 eyes and aqueous deficiency group, but there was a significant negative correlation between the total number of LIPCOFs and FBUT in non-aqueous deficiency group.
Keywords: Lid-parallel conjunctival folds, LIPCOF, Dry eye disease, Conjunctival xerosis, Tear film rupture time
Received: 22 May 2025; Accepted: 28 Jul 2025.
Copyright: © 2025 Meng and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hongyan Zhou, China-Japan Union Hospital, Jilin University, Changchun, China
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