CASE REPORT article
Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1634047
This article is part of the Research TopicCase Reports in Intensive Care Medicine 2025View all 5 articles
Red Yeast Rice-Induced Severe Rhabdomyolysis Complicated by Acute Kidney Injury and Respiratory Failure: A Case Report
Provisionally accepted
Pengmin Zhou
Zhongheng Zhang*
Yucai Hong
Huabo CaiXiaoyu ZhouShunpeng HeHaotian ZhouJie YangPengpeng ChenBoming XiaXiong LeiSuibi Yang- Department of Emergency Medicine, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, China
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Red yeast rice (RYR), a commonly used supplement with statin-like properties, is generally considered safe but may cause severe adverse effects such as rhabdomyolysis. We report a rare case of severe RYR-induced rhabdomyolysis complicated by acute kidney injury (AKI) and respiratory failure, with diaphragmatic dysfunction as a key contributing factor. A 78-year-old woman developed progressive proximal muscle weakness, dyspnea, and tea-colored urine after taking RYR (2 g/day) for one month. She rapidly progressed to respiratory failure requiring intubation and mechanical ventilation. Laboratory tests showed a peak creatine kinase (CK) of 112,985 U/L, serum myoglobin (>3,000 µg/L), and AKI. Bedside ultrasound demonstrated diaphragmatic dysfunction, while electromyography (EMG) revealed preserved nerve conduction. Myositis-specific and paraneoplastic antibody panels were negative. She received continuous renal replacement therapy (CRRT), plasma exchange (PE), hemoperfusion (HP), and supportive care. During hospitalization, she developed deep vein thrombosis (DVT), pneumonia, and ileus, all of which resolved with treatment. At discharge, she had been weaned from mechanical ventilation and had partially recovered renal and muscle function. At follow-up, she was stable, ambulating, and performing daily functions without symptom recurrence. Although her initial presentation mimicked immune-mediated necrotizing myopathy (IMNM), the absence of myositis-specific antibodies and clinical improvement without immunosuppressive therapy supported a diagnosis of toxic rhabdomyolysis. This case highlights the importance of recognizing supplement-related toxicity and initiating timely organ-targeted supportive care. This appears to be the first reported case of RYR-induced rhabdomyolysis complicated by both AKI and respiratory failure from diaphragmatic dysfunction.
Keywords: Red yeast rice, Rhabdomyolysis, Acute Kidney Injury, respiratory failure, Statin-associated myopathy
Received: 23 May 2025; Accepted: 27 Jul 2025.
Copyright: © 2025 Zhou, Zhang, Hong, Cai, Zhou, He, Zhou, Yang, Chen, Xia, Lei and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhongheng Zhang, Department of Emergency Medicine, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, China
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