ORIGINAL RESEARCH article
Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1634980
The association between Acute Gastrointestinal Injury and Mortality in Elderly Patients with Gram-positive Bacterial Bloodstream Infection in the Intensive Care Unit: A Retrospective 7-year Study from a Research Hospital in China
Provisionally accepted
- 1Fujian Provincial Hospital, Fuzhou, China
- 2People's Hospital of Changji Hui Autonomous Prefecture, Changji, China
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Background: Gram-positive bacterial bloodstream infections (GPB-BSI) are associated with high mortality in elderly ICU patients, yet prognostic factors remain understudied. Acute gastrointestinal injury (AGI), a common complication in critical illness, may exacerbate outcomes through gut-organ crosstalk. This study investigates the prognostic impact of AGI severity on 30-day mortality in elderly ICU patients with GPB-BSI. Methods: A single-center retrospective cohort study analyzed 117 ICU patients aged ≥60 years with culture-confirmed GPB-BSI (2018–2024). Data on demographics, microbiology, comorbidities, organ dysfunction, and antimicrobial therapy were collected. Multivariable Cox regression and ROC analyses assessed associations between AGI, clinical variables, and mortality. Results: The 30-day mortality rate was 49.6% (58/117), with AGI present in 12.0% (14/117). AGI severity independently predicted mortality: Grades I-II (aHR=2.80, 95%CI= 1.05~7.46) and Grades III-IV (aHR=6.89, 95%CI= 2.34~20.29). A combined SOFA-AGI score improved prognostic accuracy (AUC=0.749 vs. SOFA=0.729). Coagulase-negative staphylococci (60.3%) dominated isolates, predominantly hospital-acquired (79.4%) and catheter-related (47.0%). High resistance to penicillins (92.1%), fluoroquinolones (79.4%), and macrolides (77.0%) contrasted with retained susceptibility to linezolid (96.8%), tigecycline (92.9%), and vancomycin (94.4%). Conclusion: AGI severity is an independent predictor of mortality in elderly GPB-BSI patients. The diagnostic accuracy for mortality improves when gastrointestinal dysfunction assessment is incorporated into the SOFA score. These findings underscore the critical need for enhanced clinical attention to gastrointestinal function protection in geriatric critical ill patients.
Keywords: The elderly patients, Gram-positive Bacteria Bloodstream Infections, Intensive Care Unit, Mortality risk factors, Acute gastrointestinal injury
Received: 25 May 2025; Accepted: 01 Sep 2025.
Copyright: © 2025 Liang, Ma, Ma, Lin and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Fan Lin, Fujian Provincial Hospital, Fuzhou, China
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