ORIGINAL RESEARCH article
Front. Med.
Sec. Gastroenterology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1636039
This article is part of the Research TopicThe Gut Microbiome's Role in Gastric Cancer: Mechanisms and TherapiesView all 13 articles
Effects of a combination of Bifidobacteria quadruple viable bacteria tablets and quadruple therapy on inflammatory response and Helicobacter pylori eradication rate in patients with Helicobacter pylori positive gastric ulcers
Provisionally accepted
- Changzhou Tumor Hospital, Changzhou, China
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Objective: To explore the effects of Bifidobacteria quadruple viable bacteria tablets (Bifidobacterium infantis, Lactobacillus acidophilus, Enterococcus faecalis, and Bacillus cereus) plus quadruple therapy on inflammatory response and Helicobacter pylori (Hp) eradication rate in patients with Hp-positive gastric ulcers. Methods: One hundred patients with Hp-positive gastric ulcers admitted from January 2022 to December 2024 were divided into a control group and a study group. The former received quadruple therapy (esomeprazole magnesium enteric-coated capsules + colloidal bismuth pectin capsule + clarithromycin tablets + amoxicillin capsule). Based on quadruple therapy, the latter was added with Bifidobacteria quadruple viable bacteria tablets. Clinical symptoms, efficacy, Hp eradication rate, levels of gastrointestinal hormones and inflammatory factors, immune function, beneficial bacteria, and adverse reactions were compared. Results: After 2 weeks of treatment, the study group had lower symptom scores (P<0.05). Furthermore, the study group showed a higher total efficacy rate and Hp eradication rate (P<0.05). Compared to the control group, the study group had higher somatostatin and lower motilin, gastrin, and pepsinogen I (P<0.05). Additionally, the study group had lower interleukin-6 (IL-6), C-reactive protein (CRP), interleukin-8 (IL-8), and matrix metalloproteinase-9 (MMP-9) (P<0.05). The study group also had higher CD4+ T-cells, a higher CD4+/CD8+ ratio, and lower CD8+ T-cells (P<0.05). Moreover, the study group had increased abundance of Enterococcus faecalis, Lactobacillus acidophilus, and Bifidobacterium (P<0.05). Lastly, the study group had fewer adverse reactions (P<0.05). Conclusion: Bifidobacteria quadruple viable bacteria tablets plus quadruple therapy can improve symptoms, enhance efficacy and Hp eradication, regulate gastrointestinal hormones and inflammatory factors, boost immune function, increase beneficial bacteria, and reduce adverse reactions in patients with Hp-positive gastric ulcer.
Keywords: gastric ulcer, Helicobacter pylori, Quadruple therapy, Bifidobacteria quadruple viable bacteria tablets, Gastrointestinal Hormones, Inflammatory factors
Received: 27 May 2025; Accepted: 15 Sep 2025.
Copyright: © 2025 Jiang, Shi, Zhuang, Zhou and Zhong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Haiyan Zhong, zhonghaiyan_edu@outlook.com
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