CASE REPORT article
Front. Med.
Sec. Dermatology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1636112
A Case of Borderline Lepromatous Leprosy and Literature Review: Key Clues to Expand Clinical Diagnostic Thinking
Provisionally accepted
- Pu'er People's Hospital, Pu'er, China
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Background: Leprosy, also known as Hansen's disease, is a chronic infectious disease caused by Mycobacterium leprae. It primarily affects the skin, peripheral nerves, mucous membranes, and the eyes. If left untreated, it can lead to severe nerve damage, deformities, and permanent disabilities. According to a report by the World Health Organization in 2023, there were approximately 180,000 new cases globally. From 2014 to 2023, the total number of new cases worldwide decreased by 14.6%. Although certain achievements have been made in the prevention and control of leprosy, there are still deep-rooted misunderstandings and prejudices regarding leprosy in society. Consequently, patients and their families suffer from discrimination and exclusion in many aspects of life, making it difficult for them to truly integrate into society. Case Presentation: A 52-year-old Dai pepole woman presented with the chief complaints of "generalized edema for 6 months and erythema and numbness of the hands and feet for 3 months." Through histopathological examination, acid-fast staining, and Bacterial Index (BI) testing, she was diagnosed with borderline lepromatous leprosy. She was administered a multi-bacillary multidrug therapy (MDT-MB) regimen for anti-leprosy treatment. Conclusion: We report a case of borderline lepromatous leprosy with generalized swelling as the initial symptom and review and analyze misdiagnosed and rare cases reported in the literature. The aim is to provide clinicians with more diagnostic ideas and reference bases and to promote the further development of leprosy prevention and control work.
Keywords: Borderline lepromatous leprosy, case report, Edema, Erythema, atypical
Received: 27 May 2025; Accepted: 01 Sep 2025.
Copyright: © 2025 Lu, Wang, Wei, Wei and Hua. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Li Lu, Pu'er People's Hospital, Pu'er, China
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