STUDY PROTOCOL article
Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1636238
Dupilumab for the treatment of COPD: protocol for a systematic review and meta-analysis
Provisionally accepted
- First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China
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Introduction：Chronic obstructive pulmonary disease (COPD) is a significant global public health issue, with a high incidence and mortality burdening patients heavily.Although existing treatment methods have made certain progress, their effectiveness in intervention during acute exacerbations and long-term management remains suboptimal for some patients. In recent years, biologic agents have provided new directions for COPD treatment. Dupilumab, a humanized monoclonal antibody targeting IL-4Rα, has shown good efficacy in type 2 inflammation-related diseases; however, its efficacy and safety in COPD treatment remain to be verified.This study will assess the efficacy and safety of dupilumab in the treatment of COPD through a systematic review and meta-analysis. Randomized controlled trials (RCTs) meeting the inclusion criteria will be included, and the Population-Intervention-Comparator-Outcome-Study (PICOS) research design standard will be adopted to compare the efficacy of dupilumab against placebo or conventional treatment. The primary outcome will be the annual exacerbation rate (AER) of COPD, and the secondary outcomes will include changes in FEV1 before baseline bronchodilators, St. George's Respiratory Questionnaire (SGRQ) scores, COPD Symptom Assessment (E-RS COPD) and blood eosinophil counts. Safety will also be assessed, and the incidence of adverse reactions will be statistically analyzed. A literature search will be conducted across multiple databases, including PubMed, Embase, WOS, Cochrane Library, and Scopus. Ultimately, this study will assess the impact of dupilumab on COPD patients through meta-analysis, aiming to provide new evidence-based insights for the treatment of COPD.
Keywords: Dupilumab, COPD, protocol, type 2 inflammation, Meta - analysis
Received: 27 May 2025; Accepted: 09 Jul 2025.
Copyright: © 2025 Xue, Xiao, Huang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Minghang Wang, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China
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