ORIGINAL RESEARCH article
Front. Med.
Sec. Gastroenterology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1637102
This article is part of the Research TopicThe Role of Helicobacter in Gastric Cancer PreventionView all articles
Prognostic risk factors analysis of low-grade gastric intraepithelial neoplasia--A Single-Center Follow-Up Study
Provisionally accepted
Xin Jiang
Ziting Miao
Xuyu Chen
Jianlei Xia
Ben-Gang Zhou
Yuanyuan ChenJingwen FangQiang She
Yao-Yao Li*Min Zhang*
Yanbing Ding*- Affiliated Hospital of Yangzhou University, Yangzhou, China
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Low-grade gastric intraepithelial neoplasia (LGIN), as a precancerous lesion of gastric cancer, is of great significance in the prevention and treatment of gastric cancer. In this study, we investigated the risk factors associated with LGIN through the follow-up of LGIN patients, and provided a reliable basis for the clinical management of LGIN patients and the formulation of individualized clinical diagnosis and treatment strategies.A total of 283 patients, newly diagnosed with LGIN, were enrolled in the study. The regression of LGIN among these patients was assessed by comparing their gastroscopic and pathological findings before and after a rigorous follow-up period. The cohort was then stratified into a progressive group and a nonprogressive group. Univariate analysis and multivariate logistic regression analysis were employed to investigate the potential risk factors contributing to the progression of LGIN in these patients. Results: Among 283 LGIN patients, 8.1% demonstrated lesion progression. Notably, five cases progressed to adenocarcinoma, resulting in an overall cancer incidence rate of 1.8%. Various factors, including age, gender, family history of gastrointestinal tumors, history of alcohol consumption, preference for pickled foods, preference for strong tea, H. pylori infection, lesion location, and endoscopic lesion manifestation, were found to be correlated with the progression of LGIN (P<0.05). Multifactorial logistic regression analysis further elucidated that a history of alcohol consumption (P=0.022, OR=3.224, 95% CI: 1.183-8.782), a family history of gastrointestinal tumors (P=0.029, OR=3.526, 95% CI: 1.136-10.947), combined with H. pylori infection (P=0.024, OR=4.220, 95% CI: 1.205-14.783), lesion location in the cardia/gastric fundus (P=0.004, OR=6.838, 95% CI: 1.874-24.958), and endoscopic manifestation of an ulcerated indurated type (P=0.023, OR=5.073, 95% CI: 1.245-20.667) emerged as significant risk factors for lesion progression in LGIN patients.LGIN patients with a history of alcohol consumption, a family history of gastrointestinal tumors, a combination of H. pylori infection, and lesions located in the cardia/gastric fundus versus lesions endoscopically presenting as ulcerated depressions are more likely to progress to cancer. These risk factors provide a reliable basis for the clinical management of LGIN patients and the development of individualized clinical treatment strategies.
Keywords: low-grade intraepithelial neoplasia of gastric mucosa, follow-up, regression, Risk factors, H. pylori infection
Received: 28 May 2025; Accepted: 14 Aug 2025.
Copyright: © 2025 Jiang, Miao, Chen, Xia, Zhou, Chen, Fang, She, Li, Zhang and Ding. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yao-Yao Li, Affiliated Hospital of Yangzhou University, Yangzhou, China
Min Zhang, Affiliated Hospital of Yangzhou University, Yangzhou, China
Yanbing Ding, Affiliated Hospital of Yangzhou University, Yangzhou, China
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