CASE REPORT article
Front. Med.
Sec. Hematology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1637435
This article is part of the Research TopicEmerging Therapies in Glomerulonephritis: Focus on Complement Regulators and Novel TargetsView all articles
Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits (PGNMID):three case reports and systematic review
Provisionally accepted
- 1Shandong Second Medical University, Weifang, China
- 2Qingdao Municipal Hospital Group, Qingdao, China
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Objective: This study aimed to investigate the clinical characteristics and personalized treatment strategies for proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID). Methods: A retrospective analysis was conducted on the clinical features, pathological characteristics, and treatment regimens of three PGNMID patients. Conclusion: PGNMID patients commonly present with proteinuria, hematuria, and renal insufficiency. Pathologically, light microscopy predominantly reveals a membranoproliferative glomerulonephritis (MPGN) pattern, with IgG3κ being the most prevalent immunohistochemical subtype. Current guidelines recommend the BCD regimen (bortezomib, cyclophosphamide, dexamethasone) as first-line therapy. Daratumumab may be a safe and effective therapeutic option for PGNMID; however, clinical decision-making should comprehensively consider patient age, renal function status, treatment tolerance, and other factors.
Keywords: proliferative glomerulonephritis with monoclonal immunoglobulin deposits, Glomerulonephritis, Daratumumab, case report, Proteinuria
Received: 29 May 2025; Accepted: 28 Aug 2025.
Copyright: © 2025 Ji, Yu, Zhou, Wang, Guo and Zhong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaoqing Guo, Qingdao Municipal Hospital Group, Qingdao, China
Yuping Zhong, Qingdao Municipal Hospital Group, Qingdao, China
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