ORIGINAL RESEARCH article
Front. Med.
Sec. Nephrology
This article is part of the Research TopicManagement of Patients with Dialysis Dependent Chronic Kidney Disease (DD-CKD)View all 7 articles
The C-Reactive Protein/Albumin Ratio as a Nutritional Biomarker in Maintenance Hemodialysis Patients: A Cross-Sectional Study of Malnutrition-Inflammation Status Nutrition-Inflammation Status Assessment
Provisionally accepted
- The Affiliated Hospital of Southwest Medical University, Luzhou, China
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Background: The C-reactive protein to albumin ratio (CAR) is a biomarker associated with various diseases; however,diseases its significance in maintenance hemodialysis (MHD) patients remains unclear. This study sought to explore the relationship between the Malnutrition-Inflammation Score (MIS) and CAR in this population. Methods: In a cross-sectional study,231 adult MHD patients were enrolled and categorized into high (n = 98) and low (n = 133) MIS groups based on an optimala cutoff value of 7. -Detailed analyses were conducted on the MIS, biochemical parameters, and other biomarker ratios to assess their relationships. Results: SignificantS differences were observed in albumin, CRP, CAR, and RAR levels (all p < 0.05). A significant association was observed between CAR and MIS withMIS(OR 1.05, p < 0.001). The area under the receiver operating characteristic curve (AUROC) for CAR in identifyingidentifying nutritional and inflammatory risk was 73.85%, with an optimal cutoff value of 2.158.- A non-linear relationship was also identified between MIS and CAR. Conclusion: CAR is independently associated with the MIS in MHD patients and may serve as a valuable biomarker, underscoring its potential value for clinical nutritional management of this patient population.
Keywords: hemodialysis, Malnutrition-inflammation score, Protein-energy wasting, C-reactive protein to albumin ratio, end-stage renal disease
Received: 29 May 2025; Accepted: 30 Oct 2025.
Copyright: © 2025 Li, Jiang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dongmei Zhang, 18383070256@163.com
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