REVIEW article
Front. Med.
Sec. Geriatric Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1637992
This article is part of the Research TopicInnovations and Strategies for Comprehensive Frailty Management in Older PeopleView all 17 articles
Advancements in Research on the Anti-Aging Effects and Mechanisms of Flavonoids in Natural Products
Provisionally accepted
- Gansu University of Traditional Chinese Medicine, lanzhou city, China
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In recent years, with the continuous development of social productivity and improvements in living standards, the issue of population aging has intensified. As the elderly are susceptible to cardiovascular diseases, osteoporosis, Alzheimer's disease, and other conditions, the economic and resource burdens associated with treating, caring for, and supporting this demographic rise with their growing numbers, imposing significant pressure on societal development. In light of these challenges, research on natural products possessing anti-aging properties for treating aging-related chronic diseases has gained prominence. Flavonoids, a class of natural bioactive compounds abundantly found in plants, exhibit diverse pharmacological effects, including antioxidant, anti-inflammatory, and anti-osteoporosis activities. Therefore, studying the anti-aging effects of flavonoids is of significant value. This paper reviews recent research on the anti-aging effects of flavonoids by searching databases including CNKI, PubMed, Web of Science, and Google Scholar. The findings are summarized based on research subjects (C. elegans, animal models, and cells), effects, and mechanisms, to provide references for future in-depth research on the anti-aging effects of flavonoids.
Keywords: AGEs, Advanced glycation end products, Bcl-2, B-cell lymphoma-2, BMMSCs, Bone marrow mesenchymal stem cells, Caspase-3, cysteinyl aspartate specific proteinase-3, Gal, Galactose, GPX4, glutathione peroxidase 4, GFAP, glial fibrillary acidic protein, HO-1, heme oxygenase-1
Received: 30 May 2025; Accepted: 04 Aug 2025.
Copyright: © 2025 Wanyu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Li Wanyu, Gansu University of Traditional Chinese Medicine, lanzhou city, China
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