SYSTEMATIC REVIEW article
Front. Med.
Sec. Gene and Cell Therapy
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1640497
Ferroptosis research based on bibliometric and visual analysis: mechanism exploration and clinical application prospects in gastric cancer, prostate cancer, leukemia, and brain tumors
Provisionally accepted
Mingkun Yu1,2
Wenze Cui2,3
Wenhuan Song2,3Zujun Wang2,3Yinghua Hu4
陈文宇 陈文宇2,3Chen Tang2,3Xiaolu Ji2,3Jiantao Lv1,2*Tao Hao5*- 1Shandong University of Traditional Chinese Medicine, Jinan, China
- 2Binzhou Medical College Affiliated Traditional Chinese Medicine Hospital, BinZhou, China
- 3Binzhou Medical University, Binzhou, China
- 4Binzhou People's Hospital, Binzhou, China
- 5Department of Colorectal Hernia Surgery, Binzhou Medical University Hospital, BinZhou, China
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Purpose: Ferroptosis, iron-dependent cell death, holds significant therapeutic potential in oncology. This study aimed to map global research trends (2014-2024) of ferroptosis in gastric cancer, prostate cancer, leukemia, and brain tumors via bibliometric analysis, identifying key developments and clinical prospects. Methods: Publications from Web of Science, Scopus, and PubMed were analyzed using VOSviewer, CiteSpace for output, collaborations, influential authors/works (co-citation), and keyword trends (burst detection). Results: Research output surged, led by China and the USA. Foundational authors (Dixon, Yang, Stockwell) were highly co-cited. Emerging hotspots include overcoming therapy resistance, tumor microenvironment modulation, immunotherapy integration, and nanotechnology applications. Cancer-specific foci like GPx4 (gastric) and p53 (prostate) pathways were evident. Conclusion: This analysis provides a comprehensive map of the evolving ferroptosis research landscape across these four cancers, revealing a distinct shift towards translational applications. The findings of this study provide a valuable framework for guiding future research and for the prioritization of clinical strategies targeting ferroptosis.
Keywords: ferroptosis, gastric cancer, prostate cancer, Leukemia, brain tumors, bibliometric analysis, Lipid Peroxidation, iron metabolism
Received: 03 Jun 2025; Accepted: 17 Sep 2025.
Copyright: © 2025 Yu, Cui, Song, Wang, Hu, 陈文宇, Tang, Ji, Lv and Hao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jiantao Lv, byyt01@163.com
Tao Hao, byfyht@163.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.