ORIGINAL RESEARCH article
Front. Med.
Sec. Gastroenterology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1641325
This article is part of the Research TopicImproving the Gut Microbiome: Applications of Fecal Transplantation in Disease - Volume IIView all 5 articles
Two modified colonoscopically guided fecal microbiota transplantation catheter placement methods: a retrospective study (with video)
Provisionally accepted
- 1Southern Medical University Nanfang Hospital, Guangzhou, China
- 2Department of Gastroenterology, Shenzhen Hospital, Southern Medical University, Shenzhen, China
- 3Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Introduction: Fecal microbiota transplantation (FMT) transfers fecal microbiota from a healthy person into a patient for the treatment of various diseases. This study introduces two modified colonoscopically guided fecal microbiota transplantation catheter placement methods and evaluates their effectiveness and safety in clinical use. Methods: This study retrospectively reviewed medical records and corresponding endoscopist operational records of FMT patients at Shenzhen Hospital, Southern Medical University, from January 13, 2022, to July 26, 2024. The study analyzed 117 cases, divided into the Direct Loop Clamping (DLC) group and the Clip Loop Binding (CLB) group. The primary outcome was the catheter placement success rate. The secondary outcomes were operation-related times and adverse events. Results: Both groups achieved a 100% success rate in catheter placement. The two methods showed no significant differences in cecal intubation time, withdrawal time, and total operation time. What’s more, the CLB group had a slightly shorter time for the first endoscopic clip securement (median 1.8 minutes vs. 3.7 minutes, P=0.006). There were no significant differences in the incidence of adverse events between the two groups, and no severe adverse events were reported. Conclusions: Both modified colonoscopically guided fecal microbiota transplantation catheter placement methods demonstrated safety and effectiveness in securing the FMT catheter, meeting the needs of patients requiring multiple FMT treatments over a short period. However, further validation through large-scale randomized controlled trials is needed.
Keywords: fecal microbiota transplantation, Retrospective study, Colonoscopes, catheter, methods
Received: 04 Jun 2025; Accepted: 23 Sep 2025.
Copyright: © 2025 Li, Liu, Wang, Zhang, Wu, Fan, Ma, GONG and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wei GONG, gongwei@smu.edu.cn
Xiaxi Li, xiaxi_li@foxmail.com
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