ORIGINAL RESEARCH article
Front. Med.
Sec. Ophthalmology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1641704
This article is part of the Research TopicNew Concepts, Advances, and Future Trends in Clinical Research on Eye DiseasesView all 53 articles
Interocular Differences in Choroidal Thickness and Circulation in Anisomyopic Adults and Their Association with Myopia Severity
Provisionally accepted
- First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Purpose: To compare the interocular differences in choroidal thickness and circulation between the paired eyes of anisomyopic adults, and to further investigate the potential connection between the choroid and human myopia.Methods: 120 eyes of 60 anisomyopic adults were involved in this observational cross-sectional study, all patients underwent detailed ocular examinations, including spherical equivalent refraction (SER), axial length (AL), and other biometric parameters. Mean choroidal thickness (MCT), choriocapillaris blood flow area (CBFA), choroidal vessel volume (CVV), and choroidal vessel index (CVI)were measured on the 6 mm x 6mm macular area by Swept-Source Optical Coherence Tomography (SS-OCTA). The interocular differences in the above measurements between the paired eyes of anisomyopes were analyzed.The mean SER was -5.98 ± 1.72 diopters (D) in the more myopic eyes and -3.38 ± 1.71 D in the less myopic eyes, the mean interocular differences in SER was -2.60 ± 1.17 D. The more myopic eyes had smaller MCT, CBFA, CVV, and CVI than the relatively less myopic fellow eyes (all p < 0.01). The interocular difference in SER was positively correlated with that in MCT, CVV, and CVI (all P < 0.05), and the interocular difference in AL was negatively correlated with that in MCT, CVV, and CVI (all P < 0.05). The multiple linear regression model with generalized estimating equations showed that the interocular difference in CVV was significantly associated with the interocular difference in SER (P < 0.05).Choroidal thickness and circulation were smaller in the more myopic eyes of anisomyopic adults; the greater the interocular difference in SER, the lower choroidal thickness and circulation, indicating that the choroid is impaired in human myopia and is more likely to be compromised with severe myopia.
Keywords: Choroidal thickness, Choroidal circulation, choriocapillaris, Myopia, anisomyopia
Received: 05 Jun 2025; Accepted: 30 Jun 2025.
Copyright: © 2025 Tang, Huang, Hu, Ji, Gao, Shi, Wu and Wan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wenjuan Wan, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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