CLINICAL TRIAL article
Front. Med.
Sec. Ophthalmology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1641952
This article is part of the Research TopicNew Concepts, Advances, and Future Trends in Clinical Research on Eye DiseasesView all 58 articles
Safety and Effectiveness of a new minimally invasive glaucoma surgery namely Trabeculotome Tunnelling Trabeculoplasty in Primary Open-Angle Glaucoma
Provisionally accepted
- 1Chengdu First People's Hospital, Chengdu, China
- 2Beijing Tongren Eye Center, Beijing, China
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AIM: To report the preliminary surgical outcomes of a new minimally invasive glaucoma surgery (MIGS) namely Trabeculotome tunnelling trabeculoplasty (3T) in Primary open-angle glaucoma (POAG).This retrospective observational study with prospective follow-up included POAG patients who underwent 3T surgery at Chengdu First People's Hospital between December 2022 and June 2024. Postoperative follow-up was conducted at 1 day, 1 week, 1 month, 3 months, 6 months, and 12 months. Evaluations included intraocular pressure (IOP), number of medications, surgical success rate, and postoperative complications.Baseline mean IOP was 23.06 ± 0.72 mmHg with a median of 3 (interquartile range, IQR: 2-3) medications. Postoperative IOP significantly decreased at all follow-up points except at 1 week (p < 0.05). At 12 months, mean IOP was 16.22 ± 0.76 mmHg with a median of 0 (IQR: 0-1) medications. Complete surgical success rates were 80.0% at 6 months and 79.8% at 12 months. Early postoperative complications included IOP spikes in 34.9% and clinically significant hyphema in 6.3% (all grade 1). Cyclodialysis was rare (1.1%), and no severe adverse events were reported.CONCLUSION: 3T appears to be a safe and effective surgical option for POAG, providing sustained IOP reduction and medication burden relief with a low incidence of postoperative complications. Larger, controlled studies with longer follow-up are warranted to further validate these findings.
Keywords: Primary open-angle glaucoma, minimally invasive glaucoma surgery, Intraocular Pressure, Trabeculotome Tunnelling Trabeculoplasty, Surgical success rate
Received: 05 Jun 2025; Accepted: 05 Aug 2025.
Copyright: © 2025 Wang, Qiu, He, Fan, Jin, Zeng and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Liuzhi Zeng, Chengdu First People's Hospital, Chengdu, China
Ningli Wang, Chengdu First People's Hospital, Chengdu, China
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