CASE REPORT article
Front. Med.
Sec. Ophthalmology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1643137
This article is part of the Research TopicOphthalmology meets Microfluidics: Advances in Lab-on-a-chip technologies for Ocular HealthcareView all 3 articles
Endogenous endophthalmitis caused by Listeria monocytogenes infection in patients with end-stage renal disease
Provisionally accepted
- 1Department of Ophthalmology, Baoshan Branch, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200444, China., Shanghai, China
- 2Tongji Hospital Affiliated to Tongji University, Shanghai, China
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Purpose: This paper reports a rare case of endogenous Listeria monocytogenes endophthalmitis caused by hemodialysis in end-stage renal disease (ESRD). Methods:The patient was a 70-year-old female. The best-corrected visual acuity (BCVA) was light perception (LP). Endogenous endophthalmitis was diagnosed based on clinical manifestations and auxiliary examinations. Pathogenic microbial metagenomic detection of intraocular aqueous was used to identify Listeria monocytogenes. As multiple investigations showed no source of infection, a standardized treatment plan was proposed. Results: The treatment included the local application of antibiotics, glucocorticoids and cycloplegic drugs, vitrectomy, intravitreal injection of vancomycin and ceftazidime, anterior chamber irrigation, and systemic antibiotic treatment after the operation. After treatment, the inflammation subsided, and the BCVA at discharge was hand movement (HM). Conclusion: Our study highlights the importance of rapid pathogenic microbial metagenomic detection and timely standardized intervention in the treatment of endogenous endophthalmitis.
Keywords: Listeria monocytogenes, Endogenous endophthalmitis, pathogenic microbial metagenome, end-stage renal disease, intraocular aqueous
Received: 08 Jun 2025; Accepted: 07 Jul 2025.
Copyright: © 2025 Chen, Lv, Liu, Bi and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhen Wang, Tongji Hospital Affiliated to Tongji University, Shanghai, China
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