REVIEW article
Front. Med.
Sec. Rheumatology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1643285
This article is part of the Research TopicImpact of Autoimmune Rheumatic Diseases on Respiratory Tract Health and Advancing CareView all articles
Research progress on the effects and mechanisms of different cell types on osteoclast differentiation in bone metabolism in rheumatoid arthritis
Provisionally accepted
- 1Gansu University of Chinese Medicine, Lanzhou, China
- 2Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, China
- 3Gansu Medical College, Pingliang, China
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Rheumatoid arthritis is a systemic autoimmune disease characterized by chronic synovial inflammation, autoantibody production and progressive joint destruction. One of the main pathological features is irreversible damage and dysfunction of bone and joints, and the core pathological link is osteoclast-mediated imbalance of bone metabolism. With the advances in immunology, molecular biology and cytology, different types of cells, including T cells, B cells, macrophages, natural killer cells, synovial fibroblasts and vascular endothelial cells, activate osteoclasts in rheumatoid arthritis, leading to bone metabolism imbalance in RA and causing bone and joint damage. In this paper, we will systematically summarize the effects and mechanisms of different cell types on osteoclast differentiation in rheumatoid arthritis bone metabolism, which will provide theoretical basis and practical guidance for the precise treatment and targeted intervention of RA bone metabolism abnormalities.
Keywords: OC differentiation, bone metabolism, Rheumatoid arthritis, Research progress, the effects and mechanisms
Received: 08 Jun 2025; Accepted: 05 Aug 2025.
Copyright: © 2025 Wei, xie, Li and Hou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yingjun Wei, Gansu University of Chinese Medicine, Lanzhou, China
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