MINI REVIEW article
Front. Med.
Sec. Hematology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1644077
This article is part of the Research TopicExploring Extracellular Vesicles' Role in Hematological Disorders: Pathophysiology and Therapeutic PotentialView all 3 articles
Red Blood Cell Extracellular Vesicles: New Frontiers in Hematological Biomarker Discovery Author details
Provisionally accepted
- 1Gujarat University, Ahmedabad, India
- 2Department of Biochemistry, School of Sciences, Gujarat University, Ahmedabad, India
- 3Department of Zoology, Biomedical Technology, Human Genetics & Wildlife Biology and Conservation, Ahmedabad, Gujarat, India
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Extracellular vesicles (EVs) offer promising opportunities in hematology for improved diagnostics, prognostics, and therapeutics, making them valuable tools in the molecular landscape. EVs derived from red blood cells (RBCs) are the primary source of EVs in the bloodstream. They perform several critical biological and physiological functions, such as facilitating intercellular communication and transferring biomolecules like DNA, RNA, and proteins. Hence, in this review, we aim to explore RBC-derived EVs and their potential as a diagnostic tool for their clinical relevance and associated biomarkers in hematology. Furthermore, we emphasized their crucial role in both physiology and disease. RBC-EVs are found to play a role in vascular damage, inflammation, and coagulopathy in several pathophysiological conditions, potentially influencing the progression of certain diseases. They also served as indicators for numerous conditions, including hereditary haematologic abnormalities, diabetes, and cardiovascular diseases. Hence, their importance lies in their ability to reflect and influence red cell health, immune responses, and systemic disease states as accessible, non-invasive indicators. Also, their composition mirrors the physiological or pathological state of RBCs and holds promise for both diagnostics and therapeutics.
Keywords: Red blood cells (RBCs), Extracellular vesicles (EVs), RBC-derived EVs (RBC-EVs), biomarkers, diagnostic tool
Received: 09 Jun 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 Joshi, George and Highland. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Urja Joshi, Gujarat University, Ahmedabad, India
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