CASE REPORT article
Front. Med.
Sec. Dermatology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1644400
A case report of rapid diagnosis of Sporothrix globosa infection using MetaCAP
Provisionally accepted
- 1Department of Infectious Diseases, KingMed Diagnostics, Guangzhou, Guangdong, China
- 2Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China
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Background: Sporothrix globosa (S. globosa) is a significant pathogenic fungus responsible for causing sporotrichosis. Metagenomics Capture (MetaCAP), a high-throughput sequencing technology for pathogen nucleic acid detection based on probe capture, facilitates early diagnosis of S. globosa infections. Herein, we present a case of S. globosa infection diagnosed using MetaCAP. Case Summary: A 47-year-old female, initially diagnosed with reactive perforating collagenosis, developed epidermal erosion at the affected site after self-applying a poorly air-permeable topical patch purchased online. She subsequently exhibited progressive redness, edema, severe pruritus, and an increase in papules that coalesced into plaques following exposure to decaying wood. She revisited our hospital for further consultation. The diagnosis of sporotrichosis caused by S. globosa was confirmed through a pathological examination of the affected skin tissue and MetaCAP testing. Then, she was treated with itraconazole and naftifine hydrochloride and ketoconazole cream. After a three-month follow-up, the patient's skin rash showed significant improvement. Conclusion: A case of S. globosa infection was promptly diagnosed through MetaCAP and effectively treated with itraconazole.
Keywords: Sporotrichosis, Sporothrix globosa, MetaCAP, MNGs, Itraconazole
Received: 10 Jun 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 Li, Zhong, Guo, Liu, Song, Zhao and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Guan Jiang, Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China
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