ORIGINAL RESEARCH article
Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1645331
Bronchiectasis Morphology and Hemoptysis Recurrence After Bronchial Artery Embolization: A Cohort Study Using Inverse Probability of Treatment Weighting
Provisionally accepted
- Jiangsu University Affiliated People's Hospital, Zhenjiang, China
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Background: Hemoptysis is a serious and often life-threatening symptom associated with various pulmonary conditions, with bronchiectasis being a common cause. Bronchial artery embolization (BAE) is an effective intervention for managing hemoptysis, yet recurrence rates remain high. Several studies have identified general risk factors for recurrence. However, the role of bronchiectasis subtypes in predicting long-term outcomes after BAE has not been thoroughly explored. Objective: To assess the association between cystic bronchiectasis and the risk of hemoptysis recurrence following BAE, compared to non-cystic bronchiectasis subtypes. Methods: This retrospective cohort study included 168 adults treated with BAE for hemoptysis due to bronchiectasis from January 2017 to April 2022. Bronchiectasis was classified as cystic or non-cystic according to the Reid morphological criteria. Baseline differences between groups were adjusted using inverse probability of treatment weighting (IPTW). Results: Patients with cystic bronchiectasis exhibited a significantly higher recurrence risk than those with non-cystic bronchiectasis before and after IPTW adjustment (HR = 2.62; 95% CI, 1.42–4.82; p < 0.001). This association remained consistent across subgroup analyses stratified by age, sex, and various comorbidities, with cystic bronchiectasis consistently showing a higher recurrence risk. Conclusions: Cystic bronchiectasis is a significant independent predictor of hemoptysis recurrence following BAE. These findings suggest bronchiectasis morphology, especially cystic changes, should be recognized as an important prognostic factor when selecting candidates for BAE and planning long-term management.
Keywords: Bronchiectasis, Hemoptysis, Bronchial artery embolization, prognosis, Morphological subtype, Inverse probability of treatment weighting, Recurrence
Received: 11 Jun 2025; Accepted: 27 Aug 2025.
Copyright: © 2025 Duan, Sui, Li, Cai, Xia and Fu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jianhua Fu, Jiangsu University Affiliated People's Hospital, Zhenjiang, China
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