ORIGINAL RESEARCH article
Front. Med.
Sec. Obstetrics and Gynecology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1645567
This article is part of the Research TopicAdvances in New Biomarkers for the Diagnosis and Therapy of Gynaecological TumoursView all 8 articles
The significance of biological samples from pregnant women in cervical intraepithelial neoplasia
Provisionally accepted
- Women's Health Checkup Clinic, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China
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Background and aims Cervical cancer remains a significant threat to women’s health, with pregnant women representing a particularly vulnerable population. This study aimed to investigate the impact of cervical intraepithelial neoplasia (CIN) on pregnancy outcomes using longitudinal biological sample analysis. Methods We conducted a retrospective study of 125 pregnant women who underwent vaginal examination following abnormal cervical cytology and/or positive human papillomavirus (HPV) testing. Suspected cases underwent colposcopy-directed cervical biopsy performed by experienced clinicians (10 year of work experience) during pregnancy. Postpartum follow-up included repeat cervical cytology, HPV testing, and colposcopic biopsy when indicated. Results Among the 125 patients, 34 underwent colposcopic biopsy during pregnancy, with histopathological results demonstrating strong concordance with colposcopic findings (kappa = 0.82, *p* < 0.001). Postpartum follow-up within one year of delivery included colposcopy and cervical biopsy in 98 patients. Multivariate logistic regression analysis revealed that persistent cervical cytological abnormalities (OR 9.838; 95% CI 3.851–25.135; *p* < 0.001) were significantly associated with abnormal colposcopic findings. Conclusions For pregnant women declining cervical biopsy during pregnancy, colposcopy represents a safe and clinically valuable diagnostic tool. Persistent cervical cytological abnormalities, but not HPV positivity, were identified as a significant risk factor for CIN2+ persistence.
Keywords: Cervical Intraepithelial Neoplasia, cervical cytology, Human Papilloma Virus, Pregnancy, Colposcopy
Received: 12 Jun 2025; Accepted: 04 Sep 2025.
Copyright: © 2025 MI, Rashmi, Pan, Wu and Miao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
XUE MI, Women's Health Checkup Clinic, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China
Jinwei Miao, Women's Health Checkup Clinic, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China
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