CASE REPORT article
Front. Med.
Sec. Pathology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1645609
This article is part of the Research TopicAdvancing Intervertebral Disc Degeneration Research: Focus on Annulus Fibrosus and Pain ManagementView all 3 articles
Anaerococcus vaginalis spondylodiscitis diagnosed and cured based on nanopore targeted sequencing
Provisionally accepted
- Tongji University Dongfang Hospital, Shanghai, China
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Spondylodiscitis caused by Anaerococcus vaginalis hasn't been reported yet, making it worthy of further exploration. We closely monitored a patient who experienced worsened low back pain for 1 month and was unable to walk due to severe pain for 1 weekcannot walk on account of rapid pain for 1 week. Through thorough examinations, the patient was diagnosed with lumbar disc herniation and a suspected case of spondylodiscitis, necessitating posterior lumbar surgery. All culture results returned negative. However, nanopore targeted sequencing (NTS) identified the presence of Anaerococcus vaginalis. Subsequent administration of appropriate antibiotics resulted in a favorable clinical outcome for the patient. With comprehensive examinations, the patient was diagnosed with lumbar disc herniation as well as a suspected spondylodiscitis and underwent posterior lumbar surgery. All the culture results indicated negative findings. Nanopore targeted sequencing (NTS) suggested the presence of Anaerococcus vaginalis. Following appropriate antibiotic administration, the patient obtained a satisfactory outcome.
Keywords: Anaerococcus vaginalis, Spondylodiscitis, Nanopore targeted sequencing, diagnosis, Treatment
Received: 12 Jun 2025; Accepted: 14 Jul 2025.
Copyright: © 2025 Zhou, Guo, Shen, Zhu, Yu, Li, ZONG, Hu and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tao Hu, Tongji University Dongfang Hospital, Shanghai, China
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