Validation of the Efficacy of the GPSS Questionnaire for Screening Obstructive Sleep Apnea

Zhuoji LiHanyue LiuShuyue ZhouXiaomi ChenHuimin Xiaomi ChenQinghua Chen Qinghua ChenZhitao MiaoJunfen ChengZhaojun ChenYuli CaiHuizhao LiaoSun TingtingRiken Chen^*Lijuan ZengLishu Zhang

• Guangdong Medical University, Zhanjiang, China

This study aimed to compare the screening performance of a newly developed screening questionnaire for obstructive sleep apnea (OSA), Methods The sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve (AUC) of each OSA screening questionnaire were calculated to evaluate their diagnostic performance. Results: The prevalence of OSA was 69.3% in the first group and 79.5% in the second group. In the first group, neck circumference, waist circumference, pulse rate, systolic blood pressure, diastolic blood pressure, age, height, weight, BMI , and gender characteristics showed significant differences between the OSA group and the non-OSA group. In the comparison of sensitivity, specificity, PPV, and NPV of the five questionnaires among patients in the first group, for all OSA patients, the GPSS questionnaire had superior specificity and positive predictive value compared to other questionnaires; for moderate/severe OSA patients, the GPSS questionnaire had lower sensitivity, specificity, PPV, and NPV than the other four questionnaires. In the second group, among all OSA patients, the GPSS questionnaire had superior sensitivity, positive predictive value, and negative predictive value compared to the other questionnaires; among moderate/severe OSA patients, the GPSS questionnaire had superior specificity and positive predictive value compared to the other questionnaires. ROC analysis results showed that in the first group, the GPSS questionnaire had superior sensitivity, specificity, positive predictive value, and negative predictive value compared to the other questionnaires among all OSA patients, moderate OSA patients, and severe OSA patients, with values of 0.75 (95% CI:0.73–0.77), 0.73 (95% CI:0.71–0.75), and 0.73 (95% CI:0.71–0.75), respectively. In the second group, the GPSS questionnaire outperformed the other four scales in all OSA patients and moderate OSA patients, with values of 0.77 (95% CI:0.72–0.83) and 0.75 (95% CI:0.70–0.80), respectively. However, it still had some reference value in patients with severe OSA, with a value of 0.69 (95% CI:0.62–0.75). Conclusion .According to the ROC results, the GPSS questionnaire was superior to the other 4 scales in screening for mild-to-moderate OSA, but it still has room for improvement in severe OSA.