CLINICAL TRIAL article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1645820
Comparing the longer regimen and the shorter regimen for multidrug-resistant pulmonary tuberculosis patients treated under the programmatic management of drug-resistant tuberculosis
Provisionally accepted
- Datta Meghe Institute of Higher Education and Research Deemed to be University, Wardha, India
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Despite the significant progress made by India in the control of Tuberculosis, it remains the second leading cause of mortality among infectious diseases. Shorter treatment courses for multidrugresistant tuberculosis (MDR-TB) can enhance patient adherence by decreasing the length of time for medication intake and alleviating the challenges associated with prolonged treatment.Tuberculosis medications are associated with common side effects like hepatotoxicity, gastrointestinal problems, and peripheral neuropathy, which can compromise patient adherence and affect overall treatment success. Evaluating the effectiveness of various treatment regimens is crucial for identifying the best compromise among treatment duration, efficacy, and patient adherence.Formulating a treatment regimen with fewer adverse effects, improved compliance, and better treatment outcomes is a crucial challenge for effective disease control in the country. The study is registered in the Clinical Trials Registry-India with Registration number CTRI/2024/01/061453 and Reference number REF/2023/07/070740.
Keywords: Multidrug-resistant pulmonary tuberculosis, Culture conversion, adverse drug reactions, Malnutrition, alcohol, Smoking, Diabetes Mellitus, HIV - human immunodeficiency virus
Received: 13 Jun 2025; Accepted: 08 Aug 2025.
Copyright: © 2025 KARNAN, Jadhav, Ghewade and Alone. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: ASHWIN KARNAN, Datta Meghe Institute of Higher Education and Research Deemed to be University, Wardha, India
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