CASE REPORT article
Front. Med.
Sec. Dermatology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1647451
Reticulate Acropigmentation of Kitamura with Café-au-Lait Macules: A Rare Case Report
Provisionally accepted
- 1Department of Cosmetic Dermatology, Yixing People's Hospital, Yixing, China
- 2Department of Dermatology, The First hospital of Hebei Medical University, Shijiazhuang, China
- 3Department of Cosmetic Dermatology, Shenzhen People's Hospital, Shenzhen, China
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Abstract Reticulate acropigmentation of Kitamura (RAK) predominantly affects East Asian populations, though isolated cases and familial occurrences have been reported glo bally. Japanese researchers Kitamura et al. first described this condition in 1943. I n 2013, pathogenic variants in ADAM10 (a disintegrin and metalloprotease 10) wer e identified as causative in multiple Japanese RAK pedigrees. The occurrence of R AK with Dowling-Degos disease (DDD) is relatively well-documented. However, ra re associations with bilateral clinodactyly, nevus of Ito, dermatopathia pigmentosa r eticularis, and progressive seborrheic keratosis have also been reported. RAK is an extremely rare autosomal dominant disorder. Café-au-lait macules (CALMs) repres ent common hyperpigmented lesions, yet no documented cases of RAK-CALMs coe xistence exist in the literature to date.
Keywords: Reticulate acropigmentation of Kitamura, Café-au-lait macules, coexistence, Rare case, Treatment
Received: 15 Jun 2025; Accepted: 25 Aug 2025.
Copyright: © 2025 Gao, Wang, Fan, Cong, Zhang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Huijuan Wang, Department of Dermatology, The First hospital of Hebei Medical University, Shijiazhuang, China
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