CLINICAL TRIAL article
Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1648417
Comparative Study of Ciprofol vs. Propofol in Carotid Endarterectomy: Focusing on Mean Arterial Pressure, Vasoactive Drug Use, and Postoperative Complications
Provisionally accepted
- 1University-Town Hospital of Chongqing Medical University, Chongqing, China
- 2Children's Hospital of Chongqing Medical University, Chongqing, China
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Aim: The aim of this study was to compare the effects of ciprofol and propofol on mean arterial pressure (MAP) management, vasoactive drug usage, and postoperative complications after carotid endarterectomy. Methods: A total of 103 patients were included in either the ciprofol (n=50) or propofol (n=53) group. The MAP was recorded at nine perioperative timepoints from before anesthesia (T0) to extubation (T8). We focused on the achievement rate of the target MAP during carotid cross-clamping at T4-T6. We also examined vasopressor use (norepinephrine, urapidil) and postoperative complications. Results: In terms of primary outcomes, the ciprofol group exhibited a higher MAP at T3 (before the skin incision; p=0.006) and achieved the target MAP faster at T4-T5 (during carotid cross-clamping and 5 minutes after cross-clamping; p<0.001) than did the propofol group. There were no statistically significant differences between the groups at T6 (10 minutes after cross-clamping; p=0.360). The ciprofol group exhibited significantly better hemodynamic stability during extubation (p<0.001). Regarding the secondary outcomes, the ciprofol group was administered a lower dosage of norepinephrine (p<0.001) and had fewer cases of early cognitive dysfunction (eCD)(p=0.024). Conclusion: These findings suggest that ciprofol offers advantages over propofol during carotid endarterectomy by optimizing MAP control, minimizing vasopressor use, and mitigating postoperative complications. Ciprofol may be the preferable anesthetic agent in carotid artery-related procedures. Clinical Trial Registration: https://www.chictr.org.cn/, Identifier [ChiCTR2500104162].
Keywords: Ciprofo1, Propofo2, anesthesia3, Mean Arterial Pressure4, CarotidEndarterectomy5
Received: 17 Jun 2025; Accepted: 03 Oct 2025.
Copyright: © 2025 Zheng, Deng, Tian, Zhang and Bai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yanqing Zhang, lillyblooming@163.com
Lin Bai, 1455973437@qq.com
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