ORIGINAL RESEARCH article
Front. Med.
Sec. Translational Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1649671
Effects of bifid triple viable capsules dissolving at intestines combined with emergency comprehensive nursing on intestinal microorganism and nutritional status of patients with coronary heart disease after percutaneous coronary intervention
Provisionally accepted
Ming Zuo
Zhi Liu*- Xuanwu Hospital, Beijing, China
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Objective: To evaluate the combined effects of bifid triple viable capsules dissolving at intestines and emergency comprehensive nursing on intestinal microbiota, cardiovascular function, and nutritional status in coronary heart disease (CHD) patients post-percutaneous coronary intervention (PCI). Study Design: A randomized controlled trialprospective, randomized, controlled observational study. Place & Duration of Study: This study was conducted at Capital Medical UniversityHebei Hospital of Traditional Chinese Medicine from March 2023 to January 2024. Methodology: A total of 110 CHD patients who underwent PCI were randomized into two groups: the control group (CG, n=55) receiving routine emergency nursing, and the study group (SG, n=55) receiving emergency comprehensive nursing combined with bifid triple viable capsules (0.63 g, twice daily). Key outcomes, including left ventricular ejection fraction (LVEF), blood pressure, length of hospital stay, psychological well-being, nursing satisfaction, intestinal microbiota composition, and nutritional and lipid profiles, were measured before and after 8 weeks of intervention. Results: The SG demonstrated significantly higher improvements in LVEF and blood pressure and shorter hospital stays compared to the CG (P<0.05). Psychological well-being, self-efficacy, and nursing satisfaction scores were significantly better in the SG (P<0.05). Additionally, the SG showed greater restoration of lactobacillus and bifidobacterium levels and reduction in escherichia coli levels (P<0.05). Nutritional markers, including hemoglobin, albumin, transferrin, and prealbumin, as well as lipid profiles, such as TG, TC, LDL-C, and HDL-C, improved significantly in the SG compared to the CG (P<0.05). Conclusion: The combination of bifid triple viable capsules and emergency comprehensive nursing significantly improved cardiovascular function, reduced complications, enhanced self-efficacy and quality of life, and optimized intestinal microbiota and nutritional status in CHD patients after PCI.
Keywords: coronary heart disease, Percutaneous Coronary Intervention, emergency comprehensive nursing, complications, bifid triple viable capsules dissolving at intestines, Intestinal microorganism, Nutritional Status
Received: 18 Jun 2025; Accepted: 20 Aug 2025.
Copyright: © 2025 Zuo and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhi Liu, Xuanwu Hospital, Beijing, China
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