BRIEF RESEARCH REPORT article
Front. Med.
Sec. Hematology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1650704
This article is part of the Research TopicInnovative Modeling and Simulation in Thrombosis and Hemostasis: Enhancing Diagnosis and TreatmentView all 6 articles
Etiology of patients with extreme thrombocytosis and its association with coagulation function: ten-year experience in a tertiary hospital
Provisionally accepted
- 1Dongyang People's Hospital, Dongyang, China
- 2Department of Pharmacy, Sir Run Run Shaw Hospital, Hangzhou, China
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Background: This study aimed to analyze the etiology of extreme thrombocytosis and its influence on coagulation function. Methods: We performed a ten-year retrospective study that included patients with platelet counts greater than 1000×109/L. The etiology of extreme thrombocytosis was analyzed by physicians and compared between subgroups, which were stratified by department, age and sex. We also collected the coagulation function of inpatients, including the prothrombin time (PT), international normalized ratio, partial thromboplastin time ratio, prothrombin activity, activated partial thromboplastin time (APTT), fibrinogen, thrombin time and D-dimer, when patients were under extreme thrombocytosis. Results: Overall, 437 patients were included in the study, including 254 inpatients, 125 outpatients, and 58 emergency patients. The most common cause was myeloproliferative neoplasms (MPN), followed by infection and asplenia. However, the etiology of disease in nearly 10% (41/437) of patients is unclear. MPN was the main etiology for patients from different departments, but the second most common etiologies for inpatients, outpatients and emergency patients were infection, chronic myelogenous leukemia, and unknown, respectively. The most common cause in children is infection. There was no difference between females and males, except for asplenia. Among the inpatients, 87.5% and 60.1% of the patients had PT and D-dimer higher than the normal range, respectively. Moreover, APTT and FIB were in critical condition for 11.1% and 13.7% of the patients, respectively. Conclusion: This study provides the etiology of extreme thrombocytosis and its association with coagulation function. This study could benefit the future diagnosis and treatment of extreme thrombocytosis.
Keywords: Extreme thrombocytosis, Coagulation function, Platelet, etiology, Prothrombin Time
Received: 22 Jul 2025; Accepted: 09 Oct 2025.
Copyright: © 2025 Chen, Huang, Wu, Zhang, Yu, Chen and Ying. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhenwei Yu, yzw_srrsh@zju.edu.cn
Manzhen Ying, yingmz0579@wmu.edu.cn
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