ORIGINAL RESEARCH article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1652051
The Diagnostic Value of Combined Aspergillus IgG Antibody and Galactomannan Antigen Detection in Nonneutropenic Patients with Pulmonary Aspergillosis
Provisionally accepted
- 1General Hospital of Northern Theatre Command, Shenyang, China
- 2The 968th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Chaoyang, China
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To evaluate the diagnostic efficacy of combined Aspergillus-specific IgG antibody and galactomannan antigen testing in nonneutropenic patients with pulmonary aspergillosis. A total of 561 patients were included in the dataset for the analysis. The Asp IgG positivity rate was significantly greater in participants ultimately diagnosed with pulmonary aspergillosis than in the control group (P<0.01). Aspergillus antibody IgG had diagnostic significance for pulmonary aspergillosis (P<0.01), with an AUC of 0.748 (or 0.738 excluding ABPA), P<0.01. The optimal diagnostic cut-off for Aspergillus antibody IgG was ≥102.95 U/L. The results of the combined analysis of Aspergillus antibody IgG and the GM test revealed that negative test results for both Aspergillus antibody IgG and GM could significantly increase the diagnostic specificity, which could reach 98.3% (or 97.2% excluding ABPA). In conclusion, for clinical patients without neutropenia, Aspergillus antibody IgG in the peripheral blood is a valuable diagnostic method for pulmonary Aspergillus infection. Combining this method with the GM test can significantly increase diagnostic specificity.
Keywords: Pulmonary aspergillus infection, Aspergillus Antibody IgG, Galactomannan antigen assay, diagnosis, nonneutropenic
Received: 23 Jun 2025; Accepted: 29 Aug 2025.
Copyright: © 2025 Zhang, Ren, Deng, Zhang, Gong, Bo, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Congcong Li, General Hospital of Northern Theatre Command, Shenyang, China
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