ORIGINAL RESEARCH article
Front. Med.
Sec. Family Medicine and Primary Care
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1652992
This article is part of the Research TopicWorld Diabetes Day 2024: Exploring Mechanisms, Innovations, and Holistic Approaches in Diabetes CareView all 21 articles
Effects of Debridement Combined with Antibiotic-Loaded Bone Cement on Pain and Psychological Status in Diabetic Foot Ulcer Patients
Provisionally accepted
- 1Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China
- 2Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, China
- 3Zunyi Medical University, Zunyi, China
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This study aimed to investigate the changes in pain levels and psychological status in patients with diabetic foot ulcers (DFUs) after accepting the debridement combined with antibiotic-loaded bone cement (ALBC), which offers insight into a comprehensive treatment including pain management and psychological intervention with DFUs. We conducted a retrospective analysis of 103 patients with DFUs meeting the inclusion criteria at a tertiary academic hospital, divided into pain group (n=61) and numbness group (n=42), anxiety group (n=67) and non-anxiety group (n=36), and depression group (n=16) and non-depression group (n=87). All patients were assessed pain levels and psychological status with brief pain inventory (BPI) and hospital anxiety depression scale (HADS) before and after debridement combined with 2 ALBC. The primary outcomes were that pain degree score, pain-related impact score, and anxiety score of the depression group were higher than those of the non-depression group (P< 0.001). The total scores of pain severity and pain-related effects in the pain group decreased after debridement combined with ALBC (P=0.001, P<0.001), but these scores were always higher than those of the no-pain group (P<0.001). Moreover, the anxiety and depression scores also decreased in most patients who also had a good wound-healing process (P<0.001). These findings suggest that debridement combined with ALBC of DFU patients may be associated with alleviation of pain and improvement in psychological status in various aspects including controlling infection, promoting wound healing, and reducing frequent treatment, as a recommendation for the widespread therapy used in the clinical treatment of DFUs.
Keywords: Diabetic foot ulcer, Pain level, Psychological status, Antibiotic-loaded bone cement, Debridement
Received: 24 Jun 2025; Accepted: 12 Sep 2025.
Copyright: © 2025 Yang, Huang, Zhang, Wen, Yan, Chen, Wei and Nie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zairong Wei, zairongwei@163.com
Kaiyu Nie, 1147900529@qq.com
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