ORIGINAL RESEARCH article
Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1653269
This article is part of the Research TopicAdvances in Pharmacological Treatments for Urogenital DisordersView all 3 articles
Research on the use of tetracaine hydrochloride jelly surface anesthesia in combination with intravenous anesthesia for pain - free cystoscopy
Provisionally accepted
- 1Beijing Tsinghua Changgung Hospital, Beijing, China
- 2Tsinghua University, Beijing, China
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Abstract Objective: To evaluate the efficacy and safety of tetracaine hydrochloride jelly surface anesthesia in combination with intravenous anesthesia for painless cystoscopy. Methods: This study was conducted at the Department of Urology, Beijing Tsinghua Changgung Hospital from January 1, 2023, to December 31, 2024. A total of 60 eligible inpatients were recruited based on predefined inclusion and exclusion criteria and were randomly allocated into two groups, each comprising 30 patients. The experimental group received tetracaine hydrochloride jelly in conjunction with intravenous anesthesia, whereas the control group received intravenous anesthesia alone. Both groups were administered a slow intravenous infusion of 1.5 mg/kg propofol (1%) and 0.15 µg/kg remifentanil. After 2 minutes, the experimental group received 10 ml of tetracaine hydrochloride jelly via the urethra, while the control group received 10 ml of glycerin. The surgical procedure commenced 4 minutes later. Throughout the procedure, patients maintained spontaneous breathing, and additional propofol was administered if necessary. Preoperative parameters, including propofol dosage, cystoscopy time, anesthesia/awakening time, and relevant vital signs, were recorded for both groups. Results: Compared to the control group, the experimental group required significantly less additional propofol, had shorter anesthesia, cystoscopy,
Keywords: tetracaine hydrochloride jelly, Propofol, Surface anesthesia, Intravenous anesthesia, painless cystoscopy
Received: 25 Jun 2025; Accepted: 15 Aug 2025.
Copyright: © 2025 Bai, Luo, Wurige, Xiao and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jianxing Li, Beijing Tsinghua Changgung Hospital, Beijing, China
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