ORIGINAL RESEARCH article
Front. Med.
Sec. Translational Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1653708
Detection of Gas6/AXL complex and its expression changes in patients with STsegment elevation myocardial infarction
Provisionally accepted
- 1Department of Cardiology, The Ninth Medical Center of Chinese PLA General Hospital, Beijing, China
- 2Institute of Biophysics Chinese Academy of Sciences, Chaoyang, China
- 3Chinese PLA General Hospital, Beijing, China
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It has been reported Gas6/AXL pathway participates in several diseases. However, due of the lack of specific antibody, the significance and change circulatory Gas6/AXL complex in related diseases remain unclear. We successfully obtained an AXL monoclonal antibody only binding to Gas6/AXL complex. Using the antibody, we firstly found that AXL expressed on human pDCs had bind to Gas6. Not only applicated in flow cytometry, this novel antibody could also be used as capture antibody in ELISA. Depend on this antibody, we firstly discovered that sAXL-Gas6 complex was significantly increased in patients with AMI. Compared to AXL detected by commercial kit, AXL-Gas6 complex we measured emerged as a more sensitive biomarker and risk factor for patients with ST-segment elevation myocardial infarction.
Keywords: Gas6/AXL complex, Axl, Monoclonal antibody, Flow Cytometry, ELISA
Received: 25 Jun 2025; Accepted: 29 Jul 2025.
Copyright: © 2025 Yin, Nie, Li, Zhao, Wang, Zhang, Zhang and Shan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xuyuan Zhang, Institute of Biophysics Chinese Academy of Sciences, Chaoyang, China
Zhaoliang Shan, Chinese PLA General Hospital, Beijing, China
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