ORIGINAL RESEARCH article
Front. Med.
Sec. Ophthalmology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1654191
This article is part of the Research TopicInnovative Advancements in Eye Image Processing for Improved Ophthalmic DiagnosisView all 4 articles
Distribution Patterns and Determinants of Lens Thickness to Anterior Chamber Depth Ratio in Cataract Patients
Provisionally accepted
Chunwen ZHENG1,2,3
Wenwen Geng1,2Ruirui Ma1,2Xiaoning Hao1,2Yuling Niu1,2Duanrong Cao1,2
Yijun Hu1,2,4*Ling Jin1,2*- 1Shenzhen Baoan People's Hospital, Shenzhen, China
- 2The Second Affiliated Hospital of Shenzhen University, Shenzhen, China
- 3The Chinese University of Hong Kong, Hong Kong, Hong Kong, SAR China
- 4Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
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Background: The lens thickness to anterior chamber depth (LT/ACD) ratio remains underexplored in optimizing cataract surgical outcomes and risk stratification of potential complications in aging populations. Aims: To investigate the distribution patterns and determinants of LT/ACD ratio in cataract patients. Methods: Bilateral ocular biometrics of 715 cataract patients were measured by Lenstar LS-900. The LT/ACD ratios of right and left eyes were analyzed separately, with results of the left eyes to validate those of the right eyes. LT/ACD ratio was compared by Mann-Whitney or Kruskal-Wallis tests. Spearman’s correlations were used to evaluate its correlations to other biometrics. Univariable and multivariable linear regressions were used to identify determinants of LT/ACD ratio. Results: LT/ACD ratio was larger in females, shorter axial length (AL), and older patients (all P < 0.0001). In both eyes, LT/ACD ratio was correlated to iris center distance, pupil size (PS), angle kappa, AL, and white-to-white corneal diameter (WTW) (all P < 0.05). Determinants of LT/ACD ratio were age (β = 0.01), sex (β = -0.08), ACA (β = 0.06), angle kappa (β = 0.30), and AL (β = -0.09) in right eyes, while age (β = 0.01), sex (β = -0.08), CR (β = -0.05), angle kappa (β = 0.20), AL (β = -0.12), and WTW (β = -0.12) in left eyes. Conclusions: Distribution patterns of LT/ACD ratio varied with sex, AL, and age, and LT/ACD ratio was correlated to similar but distinct determinants in both eyes. These findings help us better understand the interaction of LT and ACD in both eyes of cataract patients.
Keywords: LT/ACD, biometrics, determinants, Cataract, Cataract surgery
Received: 26 Jun 2025; Accepted: 19 Sep 2025.
Copyright: © 2025 ZHENG, Geng, Ma, Hao, Niu, Cao, Hu and Jin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yijun Hu, huyijun2014@163.com
Ling Jin, jlingx2003@126.com
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