CASE REPORT article
Front. Med.
Sec. Hepatobiliary Diseases
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1654316
Case Report: Hepatocellular adenoma due to long-term oral stanozolol administration
Provisionally accepted
- Liaocheng People's Hospital, Liaocheng, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
This article presents a case of a 15-year-old male with a 6-year history of aplastic anemia treated with long-term oral stanozolol to promote hematopoiesis. On this occasion, the patient was admitted to hospital with abdominal pain. Abdominal imaging revealed a liver tumor of undetermined nature. A diagnosis of β-catenin-activated hepatocellular adenoma was subsequently confirmed via hepatic perforation biopsy. Stanozolol was discontinued immediately after diagnosis and replaced with platelet-boosting therapy using romiplostim. A repeat abdominal CT scan performed 4 months after discontinuation of the drug showed a significant reduction in lesion size, which continued to be closely monitored. Hepatocellular adenoma is a rare clinical scenario. This case, supported by complete data and gold-standard pathologic diagnosis, provided valuable insights, suggesting that patients on long-term androgen therapy with aplastic anemia constituted a high-risk group for hepatocellular adenoma, and highlighted the need to optimize management strategies.
Keywords: aplastic anemia, Stanozolol, Androgens, case report, Hepatocellular adenoma
Received: 26 Jun 2025; Accepted: 06 Aug 2025.
Copyright: © 2025 Qin, Tao, Guo, Liu, Luan and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wei-Chang Luan, Liaocheng People's Hospital, Liaocheng, China
Chun-Hua Liu, Liaocheng People's Hospital, Liaocheng, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.