CASE REPORT article
Front. Med.
Sec. Nephrology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1659665
Case report: A Rare Case of IgA Nephropathy Associated with Type II Abernethy Malformation
Provisionally accepted
- Xi'an No 3 Hospital, Xi'an, China
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Abernethy malformation is a rare congenital vascular anomaly involving extrahepatic portosystemic shunting, with only a handful of reported cases coexisting with IgA nephropathy. We present a case of a patient who initially manifested with proteinuria and hematuria, and later developed hepatic encephalopathy, prompting vascular imaging that identified a type II Abernethy malformation characterized by an extrahepatic portocaval shunt. A diagnosis of type II Abernethy malformation was established. The patient underwent laparoscopic partial shunt disconnection, which led to a marked reduction in proteinuria (from 0.8-2.1g/d to 0.19-0.29g/d). This case, along with previous reports, suggests that portosystemic shunting in Abernethy malformation may be a pathogenic factor in IgA nephropathy. Surgical correction of the shunt may confer renal benefits in selected cases and deserves further investigation.
Keywords: IgA nephropathy, type II Abernethy malformation, Portosystemic shunt, congenitalextrahepatic shunt disconnection, case report
Received: 04 Jul 2025; Accepted: 06 Oct 2025.
Copyright: © 2025 Cao, Guo, Zhao and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yi Gao, doctorgy1979@163.com
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