ORIGINAL RESEARCH article
Front. Med.
Sec. Obstetrics and Gynecology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1660645
This article is part of the Research TopicCutting-Edge Strategies in Screening, Prevention, and Treatment in Gynaecologic OncologyView all 37 articles
Expression and significance of PIBF combined with Galectin-1 in cervical precancerous lesions
Provisionally accepted
- Huai'an First People's Hospital, Huai'an, China
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Objective: To discuss the significance of PIBF and Galectin-1 in cervical dysplasia tissue. Methods: The expression of PIBF and Galectin-1 in precancerous tissues of cervical cancer was determined by immunohistochemical method and ELISA method, and their clinical significance was analyzed. Results: PIBF and Galectin-1 levels in cervicitis and CIN1 tissues showed no statistically significant difference; the levels of PIBF and Galectin-1 in CIN2 and CIN3 tissues were higher than those in cervicitis and CIN1, and the differences were statistically significant when compared with other groups in CIN3 group. Conclusion: Compared with the normal cervical lesion tissue, the levels of PIBF and Galectin-1 in the precervical lesion tissue were significantly increased, suggesting that their elevated levels are significantly associated with the progression of cervical intraepithelial neoplasiathey played a promoting role in the lesion progression.
Keywords: Precancerous lesion, PIBF, Galectin-1, Immunohistochemistry, Cervical Intraepithelial Neoplasia
Received: 25 Jul 2025; Accepted: 02 Oct 2025.
Copyright: © 2025 Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hong Wang, wanghong_edu@outlook.com
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