Editorial: Advancing Obstetrics and Gynecology Through Innovation, Integration, and Global Insight

Vittorio Unfer^1*Artur Wdowiak²Mattia Dominoni³Iwona Bojar⁴

• ¹Saint Camillus International University of Health and Medical Sciences, Rome, Italy
• ²Uniwersytet Medyczny w Lublinie, Lublin, Poland
• ³Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
• ⁴Institute of Rural Health, Lublin, Poland

The collections of case reports highlight the central role of physicians in clinical practice; and emphasize that obstetricians and gynecologists must remain vigilant and adaptable in addressing caseto-case variability despite the use of advanced diagnostic tools. One such report describes a case of a simultaneous intrauterine and intramural gestations in a patient who underwent ART procedures. Heterotopic pregnancy is a rare condition that is poorly described in scientific literature and even more rarely encountered in common practice. In such case, the ectopic gestation was uncovered thanks to further ultrasound investigations, which allowed prompt intervention and the preservation of pregnancy. While this case enriches the current knowledge on rare obstetric conditions, it stresses out the tremendous role of diagnostic imaging in protecting maternal and fetal health in the early phases of gestation.Similarly, unusual vaginal tuberculosis -a rare form of extrapulmonary infection -posed significant diagnostic challenges as reported by Bicha and colleagues who illustrated the risk of delayed correct diagnosis. A 35-year-old Ethiopian woman was initially misdiagnosed for pelvic organ prolapse and treated for nearly a year only to see her condition worsen. The progressive growth of the lesion prompted a more detailed investigation, and specialists established the correct diagnosis. Indeed, the initiation of targeted anti-tuberculosis therapy resulted in marked clinical improvement, underscoring the importance of maintaining diagnostic flexibility, especially in high-prevalence regions such as Ethiopia, where atypical manifestations may occur (1) When it comes to managing long-term contraceptive complications, a V-shaped copper intrauterine device (IUD), embedded in the uterine wall for over 30 years, was successfully removed using hysteroscopy. The procedure, guided by preoperative imaging and performed with meticulous dissection under direct visualization, allowed clinicians to avoid more invasive surgical interventions. This case highlights the growing potential of minimally invasive techniques in managing long-standing and complex contraceptive device complications (2). Concerning the physical health, this issue deals also with the emotional and psychological impact of gynecological and obstetric conditions. Depression among women with infertility is a significant public health concern, especially for those women living in low-resources settings, such as in African countries. Alongside economic issues, psychosocial factors such as lack of partner or family support, and previous marital difficulties were identified as major contributors to psychological distress. Integrating mental support into comprehensive infertility care, alongside medical interventions, is an essential factor to consider for improving the overall well-being of women who struggled to achieve pregnancy (3). Attention must be paid also during gestation. Preventive strategies are essential in improving maternal health, particularly in reducing the risk of preeclampsia, a major contributor to maternal and fetal complications. Kumsa et al. (4) has shown that calcium supplementation can significantly lower the incidence of this condition. Indeed, calcium plays a key role in vascular function and blood pressure regulation, and its deficiency has been strongly associated with pregnancy-related hypertension (5). The reported findings of this review strongly support calcium supplementation as a cost-effective preventive strategy, particularly beneficial during antenatal care in populations with low dietary calcium intake and at high risk for preeclampsia. Further insights into preeclampsia come from research on late-onset cases, a condition that develops after 34 weeks of gestation. Bayilis and colleagues (6) identified several key risk factors for late-onset preeclampsia, including elevated BMI, advanced maternal age, and chronic hypertension. They suggested that low-dose aspirin may offer a promising preventive approach for high-risk pregnancies, though they emphasized the need for further studies to develop more accurate and clinically applicable predictive models for late-onset preeclampsia. This collection addresses key advancements and persistent challenges in reproductive health, oncology, and perinatal care, underscoring the need of dedicated attention to women living in poor conditions. Recent findings suggest that intravaginal misoprostol may offer practical advantages over dinoprostone for labor induction. Comparative studies have shown both drugs to be similarly effective and safe, but misoprostol was associated with a significantly lower need for oxytocin augmentation. Its affordability and ease of administration make it a promising option, particularly in resource-limited settings where access to more complex treatments may be constrained (7). Moreover, researchers should further investigate the late-gynecological age. In postmenopausal osteoporosis, emerging data support the use of romosozumab as an effective therapeutic option. When added to standard treatment regimens, this monoclonal antibody has been shown to significantly reduce the risk of vertebral and non-vertebral fractures while also improving bone mineral density. Notably, no substantial increase in adverse events has been observed, reinforcing its potential as a valuable addition to current management strategies (8) In cervical cancer research, evidence indicates that women affected by HIV are at higher risk of multiple high-risk HPV infections and developing high-grade squamous intraepithelial lesions. This increased vulnerability highlights the urgent need for improved cervical cancer screening protocols and expanded HPV vaccination efforts, especially in regions with high HPV diversity and limited healthcare access (9). Finally, a detailed analysis using WHO's International Classification of Diseases for Perinatal Mortality (ICD-PM) revealed strong disparities in global perinatal outcomes. Stillbirth rates were markedly higher in low-income countries, and a considerable proportion of cases remained classified as "unspecified." These results call for enhanced data collection systems, standardized reporting practices, and targeted interventions to address preventable causes of perinatal mortality worldwide (10). An analysis of clinical trials evaluating traditional Chinese medicine and natural products for endometriosis reveals both promise and limitations. While many studies incorporated key methodological elements such as randomization and blinding, most were limited by small sample sizes and inconsistent design. These findings highlight the need for more rigorous, well-powered trials to accurately assess the potential of complementary therapies in managing chronic gynecological conditions (11). Overall, the present issue reflects the dynamic landscape of Obstetrics and Gynecology today, where technological innovation, evidence-based approaches, and global health awareness are increasingly shaping both research and clinical practice. At the same time, they underscore the critical need to integrate psychosocial and systemic perspectives, whether through better mental health support or greater inclusion of complementary medicine.These insights contribute to a growing dialogue on how best to advance reproductive and women's health through multidisciplinary collaboration, improved methodologies, and patient-centered strategies.